QuickView for SORT1;jsessionid=0691687802177092AFD76064F0A81003 (gene)

Gene Symbol:

SORT1 Homo sapiens

Full name:

sortilin 1

Synonyms:

Gp95, LDLCQ6, NT3, NTR3, sortilin, 100 kDa NT receptor, glycoprotein 95, neurotensin receptor 3

Genomic Location:

Chr 1: 109653715-109742086

Description:

This gene encodes a member of the VPS10-related sortilin family of proteins. The encoded preproprotein is proteolytically processed by furin to generate the mature receptor. This receptor plays a role in the trafficking of different proteins to either the cell surface, or subcellular compartments such as lysosomes and endosomes. Expression levels o...

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This gene encodes a member of the VPS10-related sortilin family of proteins. The encoded preproprotein is proteolytically processed by furin to generate the mature receptor. This receptor plays a role in the trafficking of different proteins to either the cell surface, or subcellular compartments such as lysosomes and endosomes. Expression levels of this gene may influence the risk of myocardial infarction in human patients. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  E12_Q6 ,  GATTGGY_NFY_Q6_01 ,  TGIF_01 ,  AAANWWTGC_UNKNOWN ,  YATTNATC_UNKNOWN ,  SRY_01 ,  TGACCTY_ERR1_Q2 ,  CTTTGTA_MIR524 ,  ALPHACP1_01 ,  CTCAGGG_MIR125B_MIR125A ,  AP1FJ_Q2 ,  GAGCTGG_MIR337 ,  CAGGGTC_MIR504 ,  ATF3_Q6 ,  ACCAAAG_MIR9 ,  SRF_Q4 ,  GTGCCAA_MIR96 ,  NFY_Q6 ,  TTGTTT_FOXO4_01 ,  MYOGENIN_Q6 ,  WTTGKCTG_UNKNOWN ,  E2F_Q2 ,  CTTTGT_LEF1_Q2 ,  CP2_01 ,  MYB_Q3

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-146 ,  Predicted Gene Targets for miR-189 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-504

Cytogenetic Map:

1p13.3::1p21.3-p13.1

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