QuickView for SPAG4 (gene)

Gene Symbol:

SPAG4 Homo sapiens

Full name:

sperm associated antigen 4

Synonyms:

CT127, SUN4, sperm-associated antigen 4 protein, SUN domain-containing protein 4, Sad1 and UNC84 domain containing 4, acrosomal protein ACR55, cancer/testis antigen 127, outer dense fiber-associated protein SPAG4, sperm tail protein

Genomic Location:

Chr 20: 33667223-33672379

Description:

The mammalian sperm flagellum contains two cytoskeletal structures associated with the axoneme: the outer dense fibers surrounding the axoneme in the midpiece and principal piece and the fibrous sheath surrounding the outer dense fibers in the principal piece of the tail. Defects in these structures are associated with abnormal tail morphology, red...

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The mammalian sperm flagellum contains two cytoskeletal structures associated with the axoneme: the outer dense fibers surrounding the axoneme in the midpiece and principal piece and the fibrous sheath surrounding the outer dense fibers in the principal piece of the tail. Defects in these structures are associated with abnormal tail morphology, reduced sperm motility, and infertility. In the rat, the protein encoded by this gene associates with an outer dense fiber protein via a leucine zipper motif and localizes to the microtubules of the manchette and axoneme during sperm tail development. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTGACGY_E4F1_Q6 ,  GGGCGGR_SP1_Q6

Cytogenetic Map:

20q11.22

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