QuickView for SPPL2B;jsessionid=1A9EBBFA634FDE91263A9CA0ED3E9F6E (gene)

Gene Symbol:

SPPL2B Homo sapiens

Full name:

signal peptide peptidase like 2B

Synonyms:

IMP-4, IMP4, PSH4, PSL1, signal peptide peptidase-like 2B, SPP-like 2B, intramembrane protease 4, presenilin homologous protein 4, presenilin-like protein 1

Genomic Location:

Chr 19: 2279629-2306100

Description:

This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release t...

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This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MIF1_01 ,  RYTGCNNRGNAAC_MIF1_01 ,  TGGTGCT_MIR29A_MIR29B_MIR29C

Cytogenetic Map:

19p13.3

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