QuickView for SPRY2;jsessionid=58322502BA86313AB0CEA76B6EB3C362 (gene)

Gene Symbol:

SPRY2 Homo sapiens

Full name:

sprouty RTK signaling antagonist 2

Synonyms:

IGAN3, hSPRY2, protein sprouty homolog 2

Genomic Location:

Chr 13: 79808112-79813087

Description:

This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells thi...

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This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  ATAAGCT_MIR21 ,  MIF1_01 ,  WHN_B ,  CREB_Q3 ,  ACTGTGA_MIR27A_MIR27B ,  CACCCBINDINGFACTOR_Q6 ,  CAGGTA_AREB6_01 ,  GGATTA_PITX2_Q2 ,  NFY_Q6_01 ,  ALPHACP1_01 ,  CAGGTG_E12_Q6 ,  TGCCTTA_MIR124A ,  GCGNNANTTCC_UNKNOWN ,  MGGAAGTG_GABP_B ,  NFY_Q6 ,  AATGTGA_MIR23A_MIR23B ,  AP2_Q6 ,  CETS1P54_01 ,  MSX1_01 ,  TEF_Q6 ,  PAX_Q6 ,  CCGNMNNTNACG_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  LXR_Q3 ,  GCTNWTTGK_UNKNOWN ,  AACTTT_UNKNOWN ,  ER_Q6 ,  PAX4_01 ,  TATTATA_MIR374 ,  GGGTGGRR_PAX4_03 ,  TCCAGAG_MIR518C

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-378

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Cytogenetic Map:

13q31.1

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