QuickView for SPTBN4 (gene)

Gene Symbol:

SPTBN4 Homo sapiens

Full name:

spectrin beta, non-erythrocytic 4

Synonyms:

CMND, QV, SPNB4, SPTBN3, spectrin beta chain, non-erythrocytic 4, beta-IV spectrin, spectrin beta chain, brain 3, spectrin, non-erythroid beta chain 3

Genomic Location:

Chr 19: 45664966-45774205

Description:

Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a famil...

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Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGTG_MIR128A_MIR128B ,  MZF1_01 ,  P53_DECAMER_Q2 ,  GATA_C ,  LXR_DR4_Q3 ,  GGGAGGRR_MAZ_Q6 ,  GTGACGY_E4F1_Q6 ,  AP1FJ_Q2 ,  GGGCGGR_SP1_Q6 ,  AAAGACA_MIR511 ,  GCM_Q2 ,  NRF2_Q4 ,  AP2_Q6 ,  ARGGGTTAA_UNKNOWN ,  PAX_Q6 ,  CGGTGTG_MIR220 ,  CCATCCA_MIR432 ,  LXR_Q3 ,  GGCKCATGS_UNKNOWN ,  GGGTGGRR_PAX4_03 ,  TCF11MAFG_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-29

Cytogenetic Map:

19q13.2

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