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QuickView for SPTLC1 (gene)

Gene Symbol:
SPTLC1 Homo sapiens Homo sapiens
Full name:
serine palmitoyltransferase long chain base subunit 1
HSAN1, HSN1, LBC1, LCB1, SPT1, SPTI, serine palmitoyltransferase 1, LCB 1, SPT 1, long chain base biosynthesis protein 1, serine C-palmitoyltransferase, serine-palmitoyl-CoA transferase 1
Genomic Location:
Chr 9: 93833248-93917511
This gene encodes a member of the class-II pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is the long chain base subunit 1 of serine palmitoyltransferase. Serine palmitoyltransferase converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate and is the key enzyme in sphingolipid biosynthesis. Mut...
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 9

GO Molecular Function

cofactor binding | transferase activity, transferring acyl groups other than amino-acyl groups | vitamin binding | coenzyme binding | pyridoxal phosphate binding | catalytic activity | transferase activity, transferring acyl groups | anion binding | palmitoyltransferase activity | ion binding | organic cyclic compound binding | vitamin B6 binding | protein binding | transferase activity | serine C-palmitoyltransferase activity | drug binding | heterocyclic compound binding | small molecule binding

GO Biological Process

regulation of autophagy | polyol metabolic process | phospholipid metabolic process | cellular process | sphingolipid metabolic process | regulation of cellular process | regulation of metabolic process | cellular lipid metabolic process | cellular nitrogen compound biosynthetic process | alcohol metabolic process | ceramide metabolic process | sphingolipid biosynthetic process | cellular nitrogen compound metabolic process | regulation of macroautophagy | cellular biosynthetic process | sphinganine biosynthetic process | organic hydroxy compound metabolic process | nitrogen compound metabolic process | phosphorus metabolic process | lipid metabolic process | organophosphate metabolic process | positive regulation of cellular metabolic process | phospholipid biosynthetic process | small molecule metabolic process | cellular amide metabolic process | biosynthetic process | diol biosynthetic process | lipid biosynthetic process | phosphate-containing compound metabolic process | regulation of cellular metabolic process | sphingomyelin metabolic process | sphingosine biosynthetic process | sphingosine metabolic process | positive regulation of lipophagy | sphingoid biosynthetic process | metabolic process | membrane lipid metabolic process | sphinganine metabolic process | organic substance metabolic process | amide biosynthetic process | positive regulation of autophagy | positive regulation of macroautophagy | sphingomyelin biosynthetic process | positive regulation of metabolic process | cellular metabolic process | ceramide biosynthetic process

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | catalytic complex | cell | palmitoyltransferase complex | intrinsic component of membrane | cytoplasm | intracellular organelle | SPOTS complex | endoplasmic reticulum | serine C-palmitoyltransferase complex | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | endomembrane system | endoplasmic reticulum membrane | transferase complex | endoplasmic reticulum palmitoyltransferase complex | membrane-bounded organelle | organelle | intracellular | membrane