QuickView for SREBP2 (gene)
- Gene Symbol:
- SREBF2
Homo sapiens - Full name:
- sterol regulatory element binding transcription factor 2
- Synonyms:
- SREBP-2, SREBP2, bHLHd2, sterol regulatory element-binding protein 2, class D basic helix-loop-helix protein 2
- Genomic Location:
- Chr 22: 40559052-40632321
- Description:
-
This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple tr...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
OCT1_B , GATA1_01 , CREB_Q4_01 , SREBP1_02 , OCT1_01 , AML_Q6 , YATGNWAAT_OCT_C , OCT_Q6 , E4BP4_01 , GCANCTGNY_MYOD_Q6
- Cytogenetic Map:
-
22q13.2
| Transcripts Names |
|---|
| NM_004599 |
| XR_001755278 |
| XM_011530347 |
| XM_017028922 |
| NR_103834 |
| XR_001755277 |
| XM_017028921 |
| XM_006724310 |
| XR_001755276 |
GO Molecular Function
sequence-specific DNA binding | intramolecular oxidoreductase activity, transposing C=C bonds | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | isomerase activity | nucleic acid binding | C-8 sterol isomerase activity | catalytic activity | RNA polymerase II regulatory region DNA binding | E-box binding | DNA binding | sequence-specific double-stranded DNA binding | intramolecular oxidoreductase activity | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | DNA-binding transcription factor activity | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | heterocyclic compound binding | protein C-terminus binding
GO Biological Process
RNA metabolic process | response to extracellular stimulus | positive regulation of macromolecule biosynthetic process | regulation of intracellular protein transport | response to nutrient levels | positive regulation of cellular component organization | regulation of cellular localization | regulation of cholesterol transport | regulation of localization | regulation of autophagy | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | negative regulation of RNA biosynthetic process | cellular response to extracellular stimulus | regulation of organelle organization | regulation of lipid transport | sterol metabolic process | positive regulation of cellular biosynthetic process | cellular process | negative regulation of nucleic acid-templated transcription | cellular response to starvation | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | cellular response to low-density lipoprotein particle stimulus | positive regulation of cholesterol storage | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | response to stimulus | regulation of cellular protein localization | positive regulation of protein targeting to mitochondrion | response to stress | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | alcohol metabolic process | response to laminar fluid shear stress | sterol homeostasis | cholesterol homeostasis | response to starvation | cellular nitrogen compound metabolic process | negative regulation of transport | regulation of protein transport | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | regulation of peptide transport | regulation of steroid biosynthetic process | cellular biosynthetic process | regulation of lipid storage | regulation of steroid metabolic process | regulation of intracellular transport | positive regulation of mitochondrion organization | regulation of nucleic acid-templated transcription | organic hydroxy compound metabolic process | response to nitrogen compound | negative regulation of cholesterol efflux | cellular response to nutrient levels | nitrogen compound metabolic process | positive regulation of organelle organization | lipid metabolic process | regulation of cholesterol biosynthetic process | regulation of gene expression | cellular response to stress | positive regulation of intracellular protein transport | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | small molecule metabolic process | cellular response to fluid shear stress | regulation of transcription by RNA polymerase II | positive regulation of lipid storage | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | regulation of cholesterol metabolic process | biosynthetic process | aromatic compound biosynthetic process | positive regulation of lipid localization | regulation of mitochondrion organization | cell communication | regulation of cellular metabolic process | homeostatic process | positive regulation of establishment of protein localization | regulation of RNA metabolic process | positive regulation of transport | regulation of lipid biosynthetic process | cellular response to lipoprotein particle stimulus | regulation of autophagy of mitochondrion | negative regulation of lipid transport | DNA-binding transcription factor activity | regulation of establishment of protein localization | response to organic substance | metabolic process | regulation of protein targeting | regulation of RNA biosynthetic process | cholesterol metabolic process | negative regulation of transcription, DNA-templated | regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter | chemical homeostasis | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | transcription, DNA-templated | positive regulation of intracellular transport | negative regulation of cholesterol transport | positive regulation of protein transport | steroid metabolic process | response to fluid shear stress | regulation of transcription, DNA-templated | cellular macromolecule biosynthetic process | regulation of cholesterol efflux | negative regulation of transcription by RNA polymerase II | regulation of transport | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | cellular response to laminar fluid shear stress | regulation of lipid metabolic process | positive regulation of metabolic process | cellular metabolic process | regulation of protein localization | lipid homeostasis | regulation of cellular component organization | positive regulation of gene expression | macromolecule metabolic process | regulation of protein targeting to mitochondrion
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | ER to Golgi transport vesicle membrane | organelle membrane | cytoplasmic vesicle | Golgi-associated vesicle membrane | cell | integral component of endoplasmic reticulum membrane | nuclear lumen | COPII-coated ER to Golgi transport vesicle | intrinsic component of membrane | transport vesicle membrane | cytoplasm | intracellular organelle | intrinsic component of endoplasmic reticulum membrane | endoplasmic reticulum | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | endomembrane system | endoplasmic reticulum membrane | nucleoplasm | Golgi-associated vesicle | vesicle | transport vesicle | mitochondrion | Golgi membrane | coated vesicle membrane | membrane-bounded organelle | nucleus | organelle | vesicle membrane | membrane-enclosed lumen | cytosol | intracellular vesicle | intracellular | membrane | SREBP-SCAP-Insig complex | cytoplasmic vesicle membrane | coated vesicle
