QuickView for SRF;jsessionid=944B4FA0D423637379D3CA652C7DA341 (gene)

Gene Symbol:

SRF Homo sapiens

Full name:

serum response factor

Synonyms:

MCM1, serum response factor, c-fos serum response element-binding transcription factor, minichromosome maintenance 1 homolog

Genomic Location:

Chr 6: 43246898-43257222

Description:

This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of man...

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This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TFIIA_Q6 ,  MAZR_01 ,  OCT1_B ,  GATA1_01 ,  VDR_Q3 ,  OCT1_01 ,  YATGNWAAT_OCT_C ,  OCT_Q6 ,  SRF_Q6 ,  CTACTGT_MIR199A ,  TGTGTGA_MIR377 ,  ACTTTAT_MIR1425P ,  MYCMAX_B ,  OCT1_Q5_01 ,  EGR2_01 ,  OCT_C ,  GTACAGG_MIR486 ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01 ,  OCT1_Q6 ,  GGGGCCC_MIR296 ,  TTGGGAG_MIR150 ,  CTCAGGG_MIR125B_MIR125A ,  AGCTCCT_MIR28 ,  YY1_01 ,  TATA_C ,  GTCTTCC_MIR7 ,  SRF_Q4 ,  HIF1_Q5 ,  CTTTAAR_UNKNOWN ,  TGCCAAR_NF1_Q6 ,  RNGTGGGC_UNKNOWN ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  PAX5_01 ,  SRF_Q5_01 ,  CAGCCTC_MIR4855P ,  CAGCTG_AP4_Q5 ,  CCAWWNAAGG_SRF_Q4 ,  SRF_C ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-122a ,  Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-150 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-28 ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-485-5p ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-486

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Cytogenetic Map:

6p21.1

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