QuickView for SSAT (gene)

Gene Symbol:

SAT1 Homo sapiens

Full name:

spermidine/spermine N1-acetyltransferase 1

Synonyms:

DC21, KFSD, KFSDX, SAT, SSAT, SSAT-1, diamine acetyltransferase 1, diamine N-acetyltransferase 1, polyamine N-acetyltransferase 1, putrescine acetyltransferase, spermidine/spermine N1-acetyltransferase alpha

Genomic Location:

Chr X: 23711225-23714248

Description:

The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene a...

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The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

IRF1_01 ,  TGANTCA_AP1_C ,  TTANTCA_UNKNOWN ,  GATA3_01 ,  E4BP4_01 ,  YATTNATC_UNKNOWN ,  VDR_Q6 ,  ATGTACA_MIR493 ,  FAC1_01 ,  MAF_Q6 ,  TGACCTY_ERR1_Q2 ,  PAX4_02 ,  PXR_Q2 ,  ZID_01 ,  RRAGTTGT_UNKNOWN ,  ATTCTTT_MIR186 ,  NKX61_01 ,  CCAWNWWNNNGGC_UNKNOWN ,  IRF_Q6 ,  OCT1_06 ,  EN1_01 ,  TTGTTT_FOXO4_01 ,  CEBP_C ,  IK2_01 ,  IRF7_01 ,  ER_Q6_01 ,  CDC5_01 ,  BRN2_01 ,  TGACATY_UNKNOWN ,  TCF1P_Q6 ,  ELF1_Q6 ,  ACACTGG_MIR199A_MIR199B ,  TCF11_01

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Cytogenetic Map:

Xp22.11

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