QuickView for STAM2;jsessionid=E3140089D06F67708964EBBFAC0287D0 (gene)

Gene Symbol:

STAM2 Homo sapiens

Full name:

signal transducing adaptor molecule 2

Synonyms:

Hbp, STAM2A, STAM2B, signal transducing adapter molecule 2, HSE1 homolog, Hrs-binding protein, STAM-2, STAM-like protein containing SH3 and ITAM domains 2, signal transducing adaptor molecule (SH3 domain and ITAM motif) 2

Genomic Location:

Chr 2: 152683352-152740752

Description:

The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stim...

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The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GGCAGCT_MIR22 ,  AAGCACA_MIR218

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-31

Cytogenetic Map:

2q23.3

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