QuickView for STC2 (gene)

Gene Symbol:

STC2 Homo sapiens

Full name:

stanniocalcin 2

Synonyms:

STC-2, STCRP, stanniocalcin-2, STC-related protein, stanniocalcin-related protein

Genomic Location:

Chr 5: 172674332-172689112

Description:

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains ...

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This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  NKX25_01 ,  E12_Q6 ,  FXR_Q3 ,  MAZR_01 ,  AGCYRWTTC_UNKNOWN ,  TGANTCA_AP1_C ,  MYOD_01 ,  TAL1ALPHAE47_01 ,  TCANNTGAY_SREBP1_01 ,  ATGTCAC_MIR489 ,  CACGTG_MYC_Q2 ,  NGFIC_01 ,  CEBP_Q2_01 ,  NFKAPPAB_01 ,  TTF1_Q6 ,  WHN_B ,  WTGAAAT_UNKNOWN ,  OSF2_Q6 ,  GGGAGGRR_MAZ_Q6 ,  GGTGTGT_MIR329 ,  CEBPDELTA_Q6 ,  CEBPB_01 ,  ACATTCC_MIR1_MIR206 ,  FOXO3_01 ,  CAGGTG_E12_Q6 ,  E47_02 ,  CATRRAGC_UNKNOWN ,  GGGCGGR_SP1_Q6 ,  CCCNNGGGAR_OLF1_01 ,  E47_01 ,  GATA1_02 ,  AHRARNT_01 ,  MYB_Q6 ,  USF_Q6_01 ,  TTGTTT_FOXO4_01 ,  ATF1_Q6 ,  CEBP_C ,  AAAYRNCTG_UNKNOWN ,  RGAGGAARY_PU1_Q6 ,  CTGAGCC_MIR24 ,  CREL_01 ,  TGACAGNY_MEIS1_01 ,  CTTTGT_LEF1_Q2 ,  AACTTT_UNKNOWN ,  MZF1_02 ,  YNGTTNNNATT_UNKNOWN ,  USF_02 ,  RRCCGTTA_UNKNOWN ,  NFKB_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-542-3p

Cytogenetic Map:

5q35.2

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