QuickView for STIM2;jsessionid=E566C0AF51054C35A1C3552402F8F739 (gene)

Gene Symbol:

STIM2 Homo sapiens

Full name:

stromal interaction molecule 2

Synonyms:

stromal interaction molecule 2

Genomic Location:

Chr 4: 26471462-26634907

Description:

This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. Th...

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This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGTG_MIR128A_MIR128B ,  STAT4_01 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  GTACTGT_MIR101 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  CTTTGA_LEF1_Q2 ,  ACTGTGA_MIR27A_MIR27B ,  TATAAA_TATA_01 ,  TGTATGA_MIR4853P ,  CAGGTA_AREB6_01 ,  GCTCTTG_MIR335 ,  HSF1_01 ,  GGGCGGR_SP1_Q6 ,  GTATGAT_MIR154_MIR487 ,  CCCNNGGGAR_OLF1_01 ,  CTTTAAR_UNKNOWN ,  HSF2_01 ,  TTGTTT_FOXO4_01 ,  YTAAYNGCT_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  RCGCANGCGY_NRF1_Q6 ,  OLF1_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-335 ,  Predicted Gene Targets for miR-409-3p ,  Predicted Gene Targets for miR-485-3p

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Cytogenetic Map:

4p15.2

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