QuickView for SV2B (gene)

Gene Symbol:

SV2B Homo sapiens

Full name:

synaptic vesicle glycoprotein 2B

Synonyms:

HsT19680, synaptic vesicle glycoprotein 2B, synaptic vesicle protein 2B homolog

Genomic Location:

Chr 15: 89570107-89639654

Description:

This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle trafficking and exocytosis. Studies in mice suggest that the encoded protein may act as a protein rece...

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This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle trafficking and exocytosis. Studies in mice suggest that the encoded protein may act as a protein receptor for botulinum neurotoxin E in neurons, and that this protein may be important for the integrity of the glomerular filtration barrier. This gene shows reduced expression in areas of synaptic loss in the hippocampus of human temporal lobe epilepsy patients.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AP1_C ,  ATF4_Q2 ,  ATGTACA_MIR493 ,  GR_Q6_01 ,  GGGAGGRR_MAZ_Q6 ,  NFE2_01 ,  STAT3_02 ,  CEBP_01 ,  CAGGTG_E12_Q6 ,  AP1_01 ,  MYOGENIN_Q6 ,  SREBP_Q3 ,  ZF5_B ,  AP1_Q4_01 ,  TCF11MAFG_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-493-5p

Cytogenetic Map:

15q26.1

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