QuickView for Slc7a11 (gene)

Gene Symbol:

SLC7A11 Homo sapiens

Full name:

solute carrier family 7 member 11

Synonyms:

CCBR1, xCT, cystine/glutamate transporter, amino acid transport system xc-, calcium channel blocker resistance protein CCBR1, solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11, solute carrier family 7, (cationic amino acid transporter, y+ system) member 11

Genomic Location:

Chr 4: 139304698-139382953

Description:

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated he...

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This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  OCT1_05 ,  TTANTCA_UNKNOWN ,  OCT1_04 ,  OCT1_01 ,  TTGCWCAAY_CEBPB_02 ,  AREB6_04 ,  TACTTGA_MIR26A_MIR26B ,  GR_Q6_01 ,  ACTGTGA_MIR27A_MIR27B ,  CEBPDELTA_Q6 ,  OCT1_Q6 ,  TTGGAGA_MIR5155P_MIR519E ,  CAGGTG_E12_Q6 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  E47_02 ,  AREB6_01 ,  CEBPB_02 ,  OCT1_03 ,  ATACTGT_MIR144 ,  AREB6_03 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  GR_01 ,  ATATGCA_MIR448 ,  SREBP_Q3 ,  TGACAGNY_MEIS1_01 ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  ACACTAC_MIR1423P

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-375

Cytogenetic Map:

4q28.3

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