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QuickView for Slit3 (gene)


Gene Symbol:
SLIT3 Homo sapiens Homo sapiens
Full name:
slit guidance ligand 3
Synonyms:
MEGF5, SLIL2, SLIT1, Slit-3, slit2, slit homolog 3 protein, multiple EGF-like domains protein 5, multiple epidermal growth factor-like domains protein 5, slit homolog 3
Genomic Location:
Chr 5: 168025857-168660554
Description:
The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 5
5q34-q35.1


Transcripts Names
NM_003062
NM_001271946
XM_017009779
Protein Names
O75094
Q9UFH5
O95804
A6H8U9



GO Molecular Function

cation binding | signaling receptor binding | ion binding | protein binding | calcium ion binding | metal ion binding | Roundabout binding

GO Biological Process

brain development | cell morphogenesis | olfactory bulb interneuron differentiation | cell motility | neuron projection morphogenesis | developmental process involved in reproduction | gonad development | female gonad development | embryonic olfactory bulb interneuron precursor migration | response to hormone | negative regulation of cellular process | cell differentiation | nervous system development | response to drug | cell part morphogenesis | neurogenesis | response to cortisol | generation of neurons | neuron projection extension | tangential migration from the subventricular zone to the olfactory bulb | cellular process | axon extension involved in axon guidance | localization | cell projection morphogenesis | heart morphogenesis | forebrain cell migration | negative regulation of signaling | developmental growth | neuron development | central nervous system neuron differentiation | reproductive system development | multicellular organismal reproductive process | regulation of response to cytokine stimulus | axon guidance | apoptotic process involved in luteolysis | forebrain neuron differentiation | ventricular septum morphogenesis | regulation of cellular process | regulation of metabolic process | cellular component organization | luteolysis | development of primary sexual characteristics | head development | response to stimulus | cell morphogenesis involved in neuron differentiation | neuron projection guidance | regulation of cell proliferation | ovulation cycle | telencephalon cell migration | programmed cell death | development of primary female sexual characteristics | reproduction | atrioventricular valve morphogenesis | response to alcohol | rhythmic process | negative regulation of metabolic process | locomotion | central nervous system neuron development | apoptotic process | cellular response to hormone stimulus | system development | reproductive process | regulation of signal transduction | negative regulation of growth | multicellular organism development | cell migration | olfactory bulb interneuron development | forebrain neuron development | telencephalon development | regulation of gene expression | axon development | response to ketone | response to lipid | animal organ morphogenesis | olfactory lobe development | response to corticosteroid | axonogenesis | aortic valve morphogenesis | cardiac septum morphogenesis | cell morphogenesis involved in differentiation | ovulation cycle process | cell communication | olfactory bulb development | semi-lunar valve development | negative regulation of chemokine-mediated signaling pathway | heart development | apoptotic process involved in development | regulation of cytokine-mediated signaling pathway | negative regulation of cell growth | neuron differentiation | multicellular organism reproduction | heart valve development | ventricular septum development | cardiac ventricle development | regulation of growth | response to organic substance | Roundabout signaling pathway | axon extension | anatomical structure development | developmental growth involved in morphogenesis | cell surface receptor signaling pathway | negative regulation of response to cytokine stimulus | cell projection organization | forebrain generation of neurons | neuron projection development | heart valve morphogenesis | cell death | negative regulation of gene expression | animal organ development | forebrain development | chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration | atrioventricular valve development | regulation of cell communication | negative regulation of signal transduction | signaling | response to organic cyclic compound | cell development | anatomical structure morphogenesis | reproductive structure development | developmental process | regulation of cell growth | cardiac septum development | negative chemotaxis | aortic valve development | negative regulation of cell proliferation | developmental cell growth | negative regulation of cytokine-mediated signaling pathway | cardiac chamber development | central nervous system development | female sex differentiation | cellular response to organic substance | sex differentiation | response to steroid hormone | circulatory system development | chemotaxis | regulation of cellular component organization | signal transduction | regulation of signaling | response to glucocorticoid | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | mitochondrion | extracellular region | membrane-bounded organelle | organelle | extracellular space | intracellular