QuickView for Sms2 (gene)

Gene Symbol:

SGMS2 Homo sapiens

Full name:

sphingomyelin synthase 2

Synonyms:

SMS2, phosphatidylcholine:ceramide cholinephosphotransferase 2, SM synthase

Genomic Location:

Chr 4: 109033879-109051558

Description:

Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze th...

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Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. Three transcript variants encoding the same protein have been found for this gene. There is evidence for more variants, but the full-length nature of their transcripts has not been determined.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AP3_Q6 ,  HEN1_01 ,  AACTGAC_MIR223 ,  TAAYNRNNTCC_UNKNOWN ,  GR_Q6_01 ,  WTGAAAT_UNKNOWN ,  CAGGTG_E12_Q6 ,  TTCYRGAA_UNKNOWN ,  CTTTAAR_UNKNOWN ,  YCATTAA_UNKNOWN ,  TAATTA_CHX10_01 ,  IK2_01 ,  CAGCTG_AP4_Q5 ,  AP4_Q5

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Cytogenetic Map:

4q25

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