QuickView for Socs1 (gene)

Gene Symbol:

SOCS1 Homo sapiens

Full name:

suppressor of cytokine signaling 1

Synonyms:

CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP-3, TIP3, suppressor of cytokine signaling 1, JAK binding protein, STAT induced SH3 protein 1, STAT-induced STAT inhibitor 1, Tec-interacting protein 3, cytokine-inducible SH2 protein 1

Genomic Location:

Chr 16: 11255775-11257540

Description:

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interf...

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This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RTAAACA_FREAC2_01 ,  PAX4_04 ,  TTTGCAC_MIR19A_MIR19B ,  MIF1_01 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01 ,  AGCATTA_MIR155 ,  STAT3_02 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  GGGCGGR_SP1_Q6 ,  IRF_Q6 ,  CCAGGGG_MIR331 ,  IRF7_01 ,  GTGGGTGK_UNKNOWN ,  ICSBP_Q6 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  AACTTT_UNKNOWN ,  CTGRYYYNATT_UNKNOWN ,  CP2_01 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-331 ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-544

Cytogenetic Map:

16p13.13

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