QuickView for SphK1 (gene)
- Gene Symbol:
- SPHK1
Homo sapiens - Full name:
- sphingosine kinase 1
- Synonyms:
- SPHK, sphingosine kinase 1, SK 1, SPK 1
- Genomic Location:
- Chr 17: 71892297-71895536
- Description:
-
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Gallus gallus , Canis lupus familiaris , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
17q25.1
GO Molecular Function
protein phosphatase 2A binding | cation binding | magnesium ion binding | transmembrane signaling receptor activity | enzyme binding | nucleic acid binding | ribonucleotide binding | nucleotide binding | G-protein coupled receptor activity | carbohydrate derivative binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | bioactive lipid receptor activity | lipid kinase activity | DNA binding | signaling receptor activity | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | D-erythro-sphingosine kinase activity | protein phosphatase binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | transferase activity | sphinganine kinase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | calmodulin binding | phosphatase binding | sphingosine-1-phosphate receptor activity | metal ion binding | heterocyclic compound binding | NAD+ kinase activity | small molecule binding
GO Biological Process
brain development | regulation of interleukin-1 beta production | regulation of muscle system process | positive regulation of locomotion | sphingoid catabolic process | intracellular signal transduction | regulation of localization | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | positive regulation of peptidyl-threonine phosphorylation | negative regulation of cellular process | positive regulation of developmental process | positive regulation of fibroblast proliferation | defense response | nervous system development | regulation of smooth muscle contraction | polyol metabolic process | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | cellular process | organic substance catabolic process | regulation of cell motility | regulation of response to cytokine stimulus | negative regulation of apoptotic process | sphingolipid metabolic process | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | regulation of angiogenesis | regulation of cellular process | positive regulation of cell growth | regulation of apoptotic process | regulation of metabolic process | catabolic process | positive regulation of cellular protein metabolic process | cellular lipid metabolic process | head development | G-protein coupled receptor activity | regulation of vasculature development | response to stimulus | vasculature development | positive regulation of NIK/NF-kappaB signaling | positive regulation of protein metabolic process | response to stress | cellular nitrogen compound biosynthetic process | alcohol metabolic process | regulation of cell proliferation | regulation of protein ubiquitination | sphingolipid biosynthetic process | cardiovascular system development | cellular nitrogen compound metabolic process | G-protein coupled receptor signaling pathway | cellular biosynthetic process | blood vessel development | regulation of nucleic acid-templated transcription | organic hydroxy compound metabolic process | system development | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | phosphorus metabolic process | regulation of muscle contraction | lipid metabolic process | regulation of phosphorylation | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of gene expression | sphingolipid mediated signaling pathway | bioactive lipid receptor activity | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | lipid kinase activity | regulation of nitrogen compound metabolic process | regulation of cell migration | small molecule metabolic process | positive regulation of intracellular signal transduction | regulation of cellular component movement | second-messenger-mediated signaling | positive regulation of cell migration | biosynthetic process | diol biosynthetic process | regulation of cellular protein metabolic process | phosphorylation | lipid biosynthetic process | membrane lipid catabolic process | phosphate-containing compound metabolic process | lipid phosphorylation | regulation of interleukin-1 production | cell communication | regulation of cellular metabolic process | positive regulation of smooth muscle contraction | cellular lipid catabolic process | inflammatory response | regulation of tumor necrosis factor-mediated signaling pathway | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | positive regulation of signal transduction | lipid modification | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of cytokine-mediated signaling pathway | regulation of locomotion | regulation of RNA metabolic process | regulation of mitotic cell cycle | positive regulation of molecular function | calcium-mediated signaling | regulation of fibroblast proliferation | D-erythro-sphingosine kinase activity | positive regulation of protein modification process | regulation of growth | sphingosine biosynthetic process | sphingosine metabolic process | sphingoid biosynthetic process | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | anatomical structure development | sphingosine-1-phosphate receptor signaling pathway | metabolic process | membrane lipid metabolic process | regulation of RNA biosynthetic process | negative regulation of programmed cell death | lipid catabolic process | positive regulation of muscle contraction | organic substance metabolic process | protein folding | animal organ development | positive regulation of NF-kappaB transcription factor activity | regulation of phosphate metabolic process | sphinganine kinase activity | organonitrogen compound catabolic process | regulation of cell communication | signaling | positive regulation of growth | regulation of transcription, DNA-templated | positive regulation of phosphorylation | regulation of cytokine production | regulation of developmental process | kinase activity | developmental process | regulation of cell growth | sphingolipid catabolic process | sphingosine-1-phosphate receptor activity | central nervous system development | positive regulation of metabolic process | cellular metabolic process | regulation of cell death | positive regulation of cell motility | negative regulation of cell death | circulatory system development | NAD+ kinase activity | positive regulation of angiogenesis | positive regulation of protein ubiquitination | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of signaling | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | plasma membrane | membrane-bounded organelle | nucleus | organelle | cell periphery | cytosol | intracellular | membrane
