QuickView for TAFII140 (gene)
- Gene Symbol:
- TAF3
Homo sapiens - Full name:
- TATA-box binding protein associated factor 3
- Synonyms:
- TAF140, TAFII-140, TAFII140, transcription initiation factor TFIID subunit 3, 140 kDa TATA box-binding protein-associated factor, RNA polymerase II transcription factor TAFII140, TAF(II)140, TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa, TBP-associated factor 3, transcription initiation factor TFIID 140 kDa subunit
- Genomic Location:
- Chr 10: 7900679-8096720
- Description:
-
The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors (Gangloff et al., 2001 [PubMed 11438666]).
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
10p14
GO Molecular Function
cation binding | p53 binding | protein heterodimerization activity | ion binding | protein binding | protein dimerization activity | metal ion binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | maintenance of protein location in nucleus | DNA-templated transcription, initiation | negative regulation of cellular process | negative regulation of RNA biosynthetic process | cellular process | localization | negative regulation of nucleic acid-templated transcription | macromolecule localization | negative regulation of cellular metabolic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular nitrogen compound biosynthetic process | protein localization to nucleus | cellular localization | cellular nitrogen compound metabolic process | maintenance of protein localization in organelle | negative regulation of metabolic process | cellular biosynthetic process | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | regulation of signal transduction | regulation of gene expression | regulation of signal transduction by p53 class mediator | regulation of nitrogen compound metabolic process | negative regulation of DNA-binding transcription factor activity | regulation of transcription by RNA polymerase II | protein localization to organelle | biosynthetic process | aromatic compound biosynthetic process | maintenance of protein location | regulation of cellular metabolic process | regulation of RNA metabolic process | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | cellular protein localization | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | maintenance of protein location in cell | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | regulation of cell communication | negative regulation of molecular function | regulation of transcription, DNA-templated | protein localization | cellular macromolecule localization | cellular macromolecule biosynthetic process | negative regulation of transcription by RNA polymerase II | heterocycle metabolic process | cellular metabolic process | regulation of signaling | macromolecule metabolic process | maintenance of location in cell
GO Cellular Component
nuclear transcription factor complex | intracellular membrane-bounded organelle | catalytic complex | organelle membrane | RNA polymerase II transcription factor complex | nuclear membrane | cell | nuclear lumen | transcription factor complex | intracellular organelle | protein-containing complex | endomembrane system | nucleoplasm | nuclear envelope | transferase complex | membrane-bounded organelle | nucleus | organelle | nuclear DNA-directed RNA polymerase complex | transcription factor TFIID complex | RNA polymerase complex | membrane-enclosed lumen | intracellular | membrane | RNA polymerase II, holoenzyme
