QuickView for TBR1 (gene)

Gene Symbol:

TBR1 Homo sapiens

Full name:

T-box, brain 1

Synonyms:

TBR-1, TES-56, T-box brain protein 1, T-brain-1

Genomic Location:

Chr 2: 161980866-161989819

Description:

This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of numerous developmental processes. In mouse, the ortholog of this gene is expressed in the cerebral cortex, hippocampus, amygdala and olfactory bulb and is thought to play an i...

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This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of numerous developmental processes. In mouse, the ortholog of this gene is expressed in the cerebral cortex, hippocampus, amygdala and olfactory bulb and is thought to play an important role in neuronal migration and axonal projection. In mouse, the C-terminal region of this protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  MYOD_Q6_01 ,  OCT1_05 ,  AGCYRWTTC_UNKNOWN ,  CEBPA_01 ,  OCT1_B ,  TTANTCA_UNKNOWN ,  OCT1_04 ,  VDR_Q3 ,  OCT1_01 ,  YTATTTTNR_MEF2_02 ,  NKX3A_01 ,  CEBP_Q2_01 ,  MEIS1BHOXA9_01 ,  HNF1_C ,  CTTTGA_LEF1_Q2 ,  NKX22_01 ,  PBX1_01 ,  CEBPB_01 ,  CCTGTGA_MIR513 ,  GGATTA_PITX2_Q2 ,  LFA1_Q6 ,  CAGGTG_E12_Q6 ,  LHX3_01 ,  MYOD_Q6 ,  ATGTTAA_MIR302C ,  TAGAACC_MIR182 ,  CEBPB_02 ,  NKX25_02 ,  CTTTAAR_UNKNOWN ,  POU1F1_Q6 ,  GFI1_01 ,  NCX_01 ,  OCT1_02 ,  CEBP_Q3 ,  TAATTA_CHX10_01 ,  AFP1_Q6 ,  YTAATTAA_LHX3_01 ,  CTCTAGA_MIR526C_MIR518F_MIR526A ,  ER_Q6_01 ,  CAGCTG_AP4_Q5 ,  MMEF2_Q6 ,  HNF1_Q6 ,  MEF2_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-375

Cytogenetic Map:

2q24.2

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