QuickView for TBS (gene)

Gene Symbol:

SALL1 Homo sapiens

Full name:

spalt like transcription factor 1

Synonyms:

HEL-S-89, HSAL1, Sal-1, TBS, ZNF794, sal-like protein 1, epididymis secretory protein Li 89, zinc finger protein 794, zinc finger protein SALL1, zinc finger protein Spalt-1

Genomic Location:

Chr 16: 49727387-49742684

Description:

The protein encoded by this gene is a zinc finger transcriptional repressor and may be part of the NuRD histone deacetylase complex (HDAC). Defects in this gene are a cause of Townes-Brocks syndrome (TBS) as well as bronchio-oto-renal syndrome (BOR). Two transcript variants encoding different isoforms have been found for this gene.

The protein encoded by this gene is a zinc finger transcriptional repressor and may be part of the NuRD histone deacetylase complex (HDAC). Defects in this gene are a cause of Townes-Brocks syndrome (TBS) as well as bronchio-oto-renal syndrome (BOR). Two transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  OCT1_07 ,  MAZR_01 ,  CEBPA_01 ,  DR3_Q4 ,  GATA1_01 ,  TTANTCA_UNKNOWN ,  MZF1_01 ,  ZIC1_01 ,  TGGNNNNNNKCCAR_UNKNOWN ,  GATA3_01 ,  E2F1_Q4_01 ,  HEN1_01 ,  YATGNWAAT_OCT_C ,  ZF5_01 ,  NKX3A_01 ,  HOXA3_01 ,  CTTTGCA_MIR527 ,  E2F_Q6_01 ,  NFKAPPAB_01 ,  TACTTGA_MIR26A_MIR26B ,  ATGTACA_MIR493 ,  AMEF2_Q6 ,  GATAAGR_GATA_C ,  SREBP1_Q6 ,  CTTTGA_LEF1_Q2 ,  STAT1_03 ,  PBX1_01 ,  MYCMAX_B ,  OCT_C ,  WHN_B ,  TAAWWATAG_RSRFC4_Q2 ,  MYAATNNNNNNNGGC_UNKNOWN ,  COMP1_01 ,  GGGAGGRR_MAZ_Q6 ,  TFIII_Q6 ,  CDP_02 ,  TGCAAAC_MIR452 ,  GTGACGY_E4F1_Q6 ,  LFA1_Q6 ,  AP4_01 ,  AP2_Q6_01 ,  ATTCTTT_MIR186 ,  NF1_Q6 ,  GGGCGGR_SP1_Q6 ,  LMO2COM_02 ,  OCT1_03 ,  NERF_Q2 ,  CCAWNWWNNNGGC_UNKNOWN ,  CTTTAAR_UNKNOWN ,  AP2_Q3 ,  NF1_Q6_01 ,  E2F_03 ,  GATA2_01 ,  E2F_Q4_01 ,  RNGTGGGC_UNKNOWN ,  AP2_Q6 ,  MTF1_Q4 ,  TAATTA_CHX10_01 ,  CCTGCTG_MIR214 ,  CART1_01 ,  GTCNYYATGR_UNKNOWN ,  PIT1_Q6 ,  MSX1_01 ,  WWTAAGGC_UNKNOWN ,  IK3_01 ,  IK1_01 ,  COUP_DR1_Q6 ,  ATAACCT_MIR154 ,  CTGCAGY_UNKNOWN ,  T3R_Q6 ,  E2F1_Q3 ,  TGATTTRY_GFI1_01 ,  WCAANNNYCAG_UNKNOWN ,  CAGCTG_AP4_Q5 ,  MMEF2_Q6 ,  CACBINDINGPROTEIN_Q6 ,  CDC5_01 ,  GCTNWTTGK_UNKNOWN ,  BRN2_01 ,  AACTTT_UNKNOWN ,  AP4_Q5 ,  MZF1_02 ,  E2F_Q3 ,  E2F_Q3_01 ,  ACCATTT_MIR522 ,  CEBPGAMMA_Q6 ,  HNF6_Q6 ,  PAX4_01 ,  CACTTTG_MIR520G_MIR520H ,  CP2_01 ,  GGGTGGRR_PAX4_03 ,  E2F1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-338 ,  Predicted Gene Targets for miR-365 ,  Predicted Gene Targets for miR-376 ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-452 ,  Predicted Gene Targets for miR-493-5p

Cytogenetic Map:

16q12.1

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