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QuickView for TCF21;jsessionid=7D1D703D6C2B949600F429147F686899 (gene)


Gene Symbol:
TCF21 Homo sapiens Homo sapiens
Full name:
transcription factor 21
Synonyms:
POD1, bHLHa23, transcription factor 21, capsulin, class A basic helix-loop-helix protein 23, epicardin, pod-1, podocyte-expressed 1
Genomic Location:
Chr 6: 134251970-134258368
Description:
TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 6
6q23.2


Transcripts Names
NM_003206
NM_198392
Protein Names
O43680
Q9BZ14
Q6ICV0
O43545
E1P581



GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | hormone receptor binding | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | signaling receptor binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | androgen receptor binding | E-box binding | bHLH transcription factor binding | DNA binding | sequence-specific double-stranded DNA binding | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nuclear hormone receptor binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | steroid hormone receptor binding | histone deacetylase binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | positive regulation of macromolecule biosynthetic process | developmental process involved in reproduction | muscle tissue development | morphogenesis of an epithelium | gonad development | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | negative regulation of RNA biosynthetic process | cell differentiation | respiratory tube development | glomerulus development | metanephric glomerulus development | mesenchyme development | blood vessel morphogenesis | positive regulation of cellular biosynthetic process | cellular process | diaphragm development | epithelial tube morphogenesis | negative regulation of signaling | reproductive system development | immune system development | negative regulation of nucleic acid-templated transcription | renal tubule morphogenesis | branching involved in ureteric bud morphogenesis | digestive tract morphogenesis | Sertoli cell differentiation | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | tissue development | metanephric nephron development | muscle structure development | skeletal muscle organ development | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | urogenital system development | nephron tubule morphogenesis | development of primary sexual characteristics | vasculature development | respiratory system development | regulation of intracellular steroid hormone receptor signaling pathway | skeletal muscle tissue development | cellular nitrogen compound biosynthetic process | roof of mouth development | tube morphogenesis | reproduction | cardiovascular system development | embryonic digestive tract morphogenesis | cellular nitrogen compound metabolic process | metanephric glomerulus morphogenesis | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | kidney development | embryo development | blood vessel development | regulation of nucleic acid-templated transcription | lung alveolus development | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | ureteric bud development | multicellular organism development | glomerulus vasculature development | spleen development | kidney morphogenesis | embryonic digestive tract development | regulation of gene expression | kidney epithelium development | mesenchymal cell differentiation involved in kidney development | positive regulation of cellular metabolic process | animal organ morphogenesis | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of intracellular steroid hormone receptor signaling pathway | biosynthetic process | aromatic compound biosynthetic process | cell differentiation involved in kidney development | angiogenesis | mesonephric epithelium development | digestive tract development | sex determination | glomerulus morphogenesis | mesonephros development | striated muscle tissue development | metanephric mesenchymal cell differentiation | regulation of cellular metabolic process | metanephros development | renal tubule development | cell differentiation involved in metanephros development | regulation of androgen receptor signaling pathway | glomerular capillary formation | lung vasculature development | regulation of RNA metabolic process | renal system development | embryonic morphogenesis | nephron development | embryonic organ morphogenesis | development of primary male sexual characteristics | ureteric bud morphogenesis | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | gland development | tissue morphogenesis | digestive system development | branching morphogenesis of an epithelial tube | male sex differentiation | anatomical structure development | metabolic process | mesenchymal cell differentiation | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | embryonic organ development | male gonad development | bronchiole development | metanephric glomerulus vasculature development | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | nephron morphogenesis | animal organ development | gene expression | metanephric glomerular capillary formation | transcription, DNA-templated | lung development | morphogenesis of a branching epithelium | anatomical structure formation involved in morphogenesis | branchiomeric skeletal muscle development | negative regulation of androgen receptor signaling pathway | regulation of cell communication | negative regulation of signal transduction | regulation of transcription, DNA-templated | morphogenesis of a branching structure | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | reproductive structure development | developmental process | negative regulation of transcription by RNA polymerase II | tube development | positive regulation of transcription, DNA-templated | metanephric mesenchyme development | positive regulation of nucleic acid-templated transcription | lung morphogenesis | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | sex differentiation | circulatory system development | mesenchymal cell differentiation involved in renal system development | nephron tubule development | muscle organ development | regulation of signaling | mesonephric tubule development | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | intracellular organelle | membrane-bounded organelle | nucleus | organelle | intracellular