QuickView for TCP-1-alpha (gene)

Gene Symbol:

TCP1 Homo sapiens

Full name:

t-complex 1

Synonyms:

CCT-alpha, CCT1, CCTa, D6S230E, TCP-1-alpha, T-complex protein 1 subunit alpha, T-complex protein 1, alpha subunit, t-complex 1 protein, tailless complex polypeptide 1

Genomic Location:

Chr 6: 160119520-160130725

Description:

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP...

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The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E2F_03 ,  E2F1_Q3 ,  E2F_Q3

Cytogenetic Map:

6q25.3

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