QuickView for TESS (gene)

Gene Symbol:

TES Homo sapiens

Full name:

testin LIM domain protein

Synonyms:

TESS, TESS-2, testin, testis derived transcript (3 LIM domains)

Genomic Location:

Chr 7: 115637817-115686073

Description:

Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs th...

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Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  SRF_Q6 ,  CTATGCA_MIR153 ,  LYF1_01 ,  TGAYRTCA_ATF3_Q6 ,  TATAAA_TATA_01 ,  IK2_01 ,  IK1_01 ,  CTTTGT_LEF1_Q2 ,  CCAATNNSNNNGCG_UNKNOWN

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-153

Cytogenetic Map:

7q31.2

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