QuickView for TFAF2 (gene)

Gene Symbol:

SNX6 Homo sapiens

Full name:

sorting nexin 6

Synonyms:

MSTP010, TFAF2, sorting nexin-6, TRAF4-associated factor 2, tumor necrosis factor receptor-associated factor 4(TRAF4)-associated factor 2

Genomic Location:

Chr 14: 34100369-34169117

Description:

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, a...

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This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTANTCA_UNKNOWN ,  AP3_Q6 ,  IPF1_Q4 ,  MYB_Q5_01 ,  TATAAA_TATA_01 ,  TITF1_Q3 ,  TGCCTTA_MIR124A ,  GTATGAT_MIR154_MIR487 ,  PITX2_Q2

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u

Cytogenetic Map:

14q13.1

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