THAP-type zinc finger QuickView - Correlation Engine

Description:: The THAP-type zinc finger (consensus: C-x(2,4)-C-x(35,50)-C-x(2)-H) is an~90-residue domain restricted to animals, which is shared between the THAPfamily of cellular DNA-binding proteins, and transposases from mobile genomicparasites. THAP1, the prototype of the THAP family, possesseszinc-dependent sequence-specific DNA binding activity and recognizes aconsensus DNA target sequence of 11 nucleotides. The THAP-type zinc fingercan be found in one or more copies and can be associated with other domains,such as the C2H2-type zinc finger.The structure of the THAP-type zinc finger reveals thepresence between the C2CH zinc coordinating residues of a short antiparallelbeta-sheet interspersed by a long loop-helix-loop insertion. Thisloop-helix-loop motif has been shown to be essential for the identification ofa number of critical residues for DNA recognition.

QuickView for THAP-type zinc finger (biogroup)