QuickView for TIMAP (gene)

Gene Symbol:

PPP1R16B Homo sapiens

Full name:

protein phosphatase 1 regulatory subunit 16B

Synonyms:

ANKRD4, TIMAP, protein phosphatase 1 regulatory inhibitor subunit 16B, CAAX box protein TIMAP, TGF-beta-inhibited membrane-associated protein, ankyrin repeat domain protein 4, ankyrin repeat domain-containing protein 4, hTIMAP, protein phosphatase 1, regulatory (inhibitor) subunit 16B

Genomic Location:

Chr 20: 36867762-36985081

Description:

The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling...

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The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGCC_MIR34A_MIR34C_MIR449 ,  ETS_Q4 ,  RYTTCCTG_ETS2_B ,  HEN1_01 ,  YTATTTTNR_MEF2_02 ,  CATTGTYY_SOX9_B1 ,  GCANCTGNY_MYOD_Q6 ,  AMEF2_Q6 ,  ZIC3_01 ,  TGACCTY_ERR1_Q2 ,  CTTTGTA_MIR524 ,  GGGAGGRR_MAZ_Q6 ,  SOX9_B1 ,  CCTGTGA_MIR513 ,  GGATTA_PITX2_Q2 ,  CAGGTG_E12_Q6 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  CAGCTTT_MIR320 ,  EGR_Q6 ,  ACTACCT_MIR196A_MIR196B ,  TGCTGAY_UNKNOWN ,  ATACTGT_MIR144 ,  HMEF2_Q6 ,  YCATTAA_UNKNOWN ,  AREB6_03 ,  RNGTGGGC_UNKNOWN ,  YTAAYNGCT_UNKNOWN ,  HEN1_02 ,  CP2_02 ,  ZIC2_01 ,  GTGGGTGK_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  MMEF2_Q6 ,  BRN2_01 ,  TGACCTTG_SF1_Q6 ,  LMO2COM_01 ,  STAT5A_02 ,  MEF2_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-196 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-370

Cytogenetic Map:

20q11.23

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