QuickView for TIP-1 (gene)

Gene Symbol:

TAX1BP3 Homo sapiens

Full name:

Tax1 binding protein 3

Synonyms:

TIP-1, TIP1, tax1-binding protein 3, Tax interaction protein 1, Tax1 (human T-cell leukemia virus type I) binding protein 3, glutaminase-interacting protein 3, tax-interacting protein 1

Genomic Location:

Chr 17: 3512938-3518722

Description:

This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play role...

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This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

POU6F1_01 ,  GCCATNTTG_YY1_Q6 ,  TATAAA_TATA_01 ,  YY1_Q6 ,  GGGCGGR_SP1_Q6 ,  PAX6_01 ,  RGAGGAARY_PU1_Q6 ,  CTTTGT_LEF1_Q2 ,  TBP_01 ,  GGGTGGRR_PAX4_03

Cytogenetic Map:

17p13.2

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