QuickView for TIPRL (gene)
- Gene Symbol:
- TIPRL
Homo sapiens - Full name:
- TOR signaling pathway regulator
- Synonyms:
- TIP, TIP41, TIPRL1, TIP41-like protein, TIP41, TOR signaling pathway regulator-like, putative MAPK-activating protein PM10, type 2A-interacting protein
- Genomic Location:
- Chr 1: 166414795-166437976
- Description:
-
TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
CREBP1CJUN_01 , CREB_Q4_01 , ATF4_Q2 , CREB_Q4 , TGAYRTCA_ATF3_Q6 , ATF_B , CREBP1_Q2 , ATF_01 , SP1_Q4_01 , HNF4_Q6
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
1q24.2
GO Molecular Function
oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor | catalytic activity | oxidoreductase activity, acting on a sulfur group of donors | protein binding | methionine-R-sulfoxide reductase activity | oxidoreductase activity
GO Biological Process
regulation of dephosphorylation | intracellular signal transduction | negative regulation of cellular process | regulation of phosphatase activity | oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor | cellular process | TOR signaling | regulation of cell cycle | negative regulation of cellular metabolic process | regulation of cellular process | regulation of metabolic process | negative regulation of phosphatase activity | response to stimulus | response to stress | negative regulation of metabolic process | negative regulation of phosphate metabolic process | negative regulation of catalytic activity | cellular response to DNA damage stimulus | regulation of catalytic activity | oxidoreductase activity, acting on a sulfur group of donors | cellular response to stress | regulation of nitrogen compound metabolic process | regulation of cellular protein metabolic process | negative regulation of protein dephosphorylation | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | methionine-R-sulfoxide reductase activity | regulation of protein dephosphorylation | metabolic process | oxidation-reduction process | negative regulation of cellular protein metabolic process | regulation of phosphate metabolic process | negative regulation of cell cycle | negative regulation of protein metabolic process | negative regulation of molecular function | signaling | negative regulation of phosphoprotein phosphatase activity | regulation of phosphoprotein phosphatase activity | negative regulation of dephosphorylation | negative regulation of hydrolase activity | oxidoreductase activity | DNA damage checkpoint | cell cycle checkpoint | signal transduction | regulation of phosphorus metabolic process
GO Cellular Component
cell | cytoplasm | cytosol | intracellular
