QuickView for TIS21 (gene)
- Gene Symbol:
- BTG2
Homo sapiens - Full name:
- BTG anti-proliferation factor 2
- Synonyms:
- APRO1, PC3, TIS21, protein BTG2, B-cell translocation gene 2, BTG family member 2, NGF-inducible anti-proliferative protein PC3, nerve growth factor-inducible anti-proliferative, pheochromacytoma cell-3
- Genomic Location:
- Chr 1: 201541287-201545353
- Description:
-
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Canis lupus familiaris , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for let-7 , Predicted Gene Targets for miR-103 , Predicted Gene Targets for miR-128 , Predicted Gene Targets for miR-132 , Predicted Gene Targets for miR-15 , Predicted Gene Targets for miR-20 , Predicted Gene Targets for miR-21 , Predicted Gene Targets for miR-25 , Predicted Gene Targets for miR-27 , Predicted Gene Targets for miR-34b
- miRNA binding sites
(Source: miRecords):
- Cytogenetic Map:
-
1q32.1
GO Molecular Function
RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | protein binding | DNA-binding transcription factor activity | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
GO Biological Process
RNA metabolic process | brain development | regulation of cell cycle process | muscle tissue development | intracellular signal transduction | regulation of cell cycle G1/S phase transition | regulation of programmed cell death | hippocampus development | response to hormone | negative regulation of neuron death | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | negative regulation of RNA biosynthetic process | cell differentiation | nervous system development | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | neurogenesis | generation of neurons | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | pattern specification process | regulation of neuron death | cellular process | mitotic DNA integrity checkpoint | neuron development | negative regulation of G1/S transition of mitotic cell cycle | central nervous system neuron differentiation | negative regulation of nucleic acid-templated transcription | learning | negative regulation of apoptotic process | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | muscle structure development | positive regulation of mRNA catabolic process | skeletal muscle organ development | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | signal transduction involved in mitotic DNA damage checkpoint | cellular component organization | head development | associative learning | response to stimulus | regulation of mitotic cell cycle phase transition | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | response to stress | skeletal muscle tissue development | cellular nitrogen compound biosynthetic process | posttranscriptional regulation of gene expression | regulation of cell proliferation | response to peptide | regulation of cell cycle phase transition | cellular nitrogen compound metabolic process | negative regulation of metabolic process | protein modification process | cellular biosynthetic process | macromolecule modification | DNA repair | anterior/posterior pattern specification | regulation of nucleic acid-templated transcription | response to nitrogen compound | negative regulation of neuron apoptotic process | central nervous system neuron development | system development | nitrogen compound metabolic process | negative regulation of mitotic cell cycle phase transition | DNA damage response, signal transduction by p53 class mediator | mitotic DNA damage checkpoint | multicellular organism development | learning or memory | cellular response to DNA damage stimulus | telencephalon development | positive regulation of cell cycle | signal transduction in response to DNA damage | regulation of gene expression | methylation | cellular response to stress | nervous system process | cell cycle | regulation of cell cycle arrest | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | cognition | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | signal transduction involved in cell cycle checkpoint | mitotic G1 DNA damage checkpoint | striated muscle tissue development | cell communication | regulation of cellular metabolic process | regulation of neuron apoptotic process | dentate gyrus development | regulation of protein metabolic process | limbic system development | regulation of RNA metabolic process | regulation of mitotic cell cycle | positive regulation of cell cycle arrest | neuron differentiation | protein metabolic process | DNA-binding transcription factor activity | regionalization | response to organic substance | G1 DNA damage checkpoint | DNA metabolic process | response to mechanical stimulus | anatomical structure development | mitotic cell cycle | regulation of neural precursor cell proliferation | cell projection organization | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | negative regulation of mitotic cell cycle | behavior | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | neuron projection development | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | regulation of mRNA catabolic process | forebrain development | pallium development | negative regulation of cellular protein metabolic process | gene expression | signal transduction involved in mitotic cell cycle checkpoint | negative regulation of translation | transcription, DNA-templated | negative regulation of cell cycle | negative regulation of protein metabolic process | negative regulation of cell cycle G1/S phase transition | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | cell development | cellular protein metabolic process | cellular macromolecule biosynthetic process | protein methylation | signal transduction involved in DNA damage checkpoint | developmental process | positive regulation of cell cycle process | cellular protein modification process | mitotic G1/S transition checkpoint | negative regulation of transcription by RNA polymerase II | negative regulation of cell proliferation | negative regulation of neural precursor cell proliferation | response to organonitrogen compound | heterocycle metabolic process | response to electrical stimulus | regulation of nuclear-transcribed mRNA poly(A) tail shortening | signal transduction involved in mitotic G1 DNA damage checkpoint | central nervous system development | positive regulation of metabolic process | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | regulation of cell death | DNA damage checkpoint | regulation of translation | cell cycle checkpoint | signal transduction by p53 class mediator | negative regulation of cell death | skeletal muscle cell differentiation | muscle organ development | signal transduction | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | cytosol | intracellular
