QuickView for TLR8 (gene)

Gene Symbol:

TLR8 Homo sapiens

Full name:

toll like receptor 8

Synonyms:

CD288, toll-like receptor 8

Genomic Location:

Chr X: 12834679-12851209

Description:

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are exp...

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The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CEBPA_01 ,  TGANNYRGCA_TCF11MAFG_01 ,  CEBP_Q2_01 ,  TTCYRGAA_UNKNOWN ,  TGCCAAR_NF1_Q6 ,  CEBP_Q3 ,  STAT5A_04 ,  CTTTGT_LEF1_Q2

Cytogenetic Map:

Xp22.2

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