QuickView for TMC8 (gene)

Gene Symbol:

TMC8 Homo sapiens

Full name:

transmembrane channel like 8

Synonyms:

EV2, EVER2, EVIN2, transmembrane channel-like protein 8, epidermodysplasia verruciformis 2, epidermodysplasia verruciformis protein 2

Genomic Location:

Chr 17: 73638464-73649033

Description:

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integra...

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Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Cytogenetic Map:

17q25.3

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