QuickView for TNFAIP6 (gene)

Gene Symbol:

TNFAIP6 Homo sapiens

Full name:

TNF alpha induced protein 6

Synonyms:

TSG-6, TSG6, tumor necrosis factor-inducible gene 6 protein, TNF-stimulated gene 6 protein, hyaluronate-binding protein, tumor necrosis factor alpha-inducible protein 6, tumor necrosis factor, alpha induced protein 6, tumor necrosis factor-stimulated gene-6 protein

Genomic Location:

Chr 2: 151922351-151944806

Description:

The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor ...

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The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Cytogenetic Map:

2q23.3

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