QuickView for TNFSF14;jsessionid=9B3D5E622A42184453EFFC4B998B6C0F (gene)

Gene Symbol:

TNFSF14 Homo sapiens

Full name:

TNF superfamily member 14

Synonyms:

CD258, HVEML, LIGHT, LTg, tumor necrosis factor ligand superfamily member 14, herpesvirus entry mediator ligand, tumor necrosis factor (ligand) superfamily, member 14, tumor necrosis factor ligand 1D, tumor necrosis factor superfamily member 14

Genomic Location:

Chr 19: 6615560-6621599

Description:

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid ...

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The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CEBP_Q2_01 ,  CEBPB_01 ,  RGAGGAARY_PU1_Q6

Cytogenetic Map:

19p13.3

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