QuickView for TNFSF18 (gene)
- Gene Symbol:
- TNFSF18
Homo sapiens - Full name:
- TNF superfamily member 18
- Synonyms:
- AITRL, GITRL, TL6, TNLG2A, hGITRL, tumor necrosis factor ligand superfamily member 18, AITR ligand, GITR ligand, activation-inducible TNF-related ligand, glucocorticoid-induced TNF-related ligand, glucocorticoid-induced TNFR-related protein ligand, tumor necrosis factor (ligand) superfamily, member 18, tumor necrosis factor ligand 2A, tumor necrosis factor superfamily member 18
- Genomic Location:
- Chr 1: 171276983-171286726
- Description:
-
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for inter...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Canis lupus familiaris , Pan troglodytes , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
HOXA4_Q2 , LYF1_01 , NFKAPPAB_01 , NFKAPPAB65_01 , STAT3_02 , HMGIY_Q6 , IK2_01 , IK3_01 , IK1_01 , GTGGGTGK_UNKNOWN
- Cytogenetic Map:
-
1q25.1
GO Molecular Function
signaling receptor binding | cytokine receptor binding | molecular function regulator | identical protein binding | protein binding | receptor regulator activity | receptor ligand activity | cytokine activity | tumor necrosis factor receptor superfamily binding
GO Biological Process
adaptive immune response | positive regulation of locomotion | response to cytokine | regulation of localization | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | regulation of immune system process | negative regulation of cellular process | cellular response to tumor necrosis factor | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | cellular process | regulation of cell motility | negative regulation of apoptotic process | regulation of tyrosine phosphorylation of STAT protein | positive regulation of nitrogen compound metabolic process | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | positive regulation of cellular protein metabolic process | T cell activation | response to stimulus | regulation of peptidyl-tyrosine phosphorylation | positive regulation of immune system process | positive regulation of protein metabolic process | mononuclear cell proliferation | positive regulation of JAK-STAT cascade | leukocyte activation involved in immune response | regulation of cell proliferation | regulation of cell adhesion | cell-cell signaling | molecular function regulator | regulation of nucleic acid-templated transcription | regulation of signal transduction | regulation of phosphorylation | regulation of T cell activation | regulation of gene expression | T cell proliferation involved in immune response | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | regulation of nitrogen compound metabolic process | regulation of cell migration | positive regulation of STAT cascade | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | regulation of cellular component movement | positive regulation of cell migration | cellular response to cytokine stimulus | cell proliferation | leukocyte proliferation | regulation of cellular protein metabolic process | T cell activation involved in immune response | regulation of leukocyte migration | cell communication | regulation of cellular metabolic process | positive regulation of tyrosine phosphorylation of STAT protein | cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | regulation of locomotion | regulation of RNA metabolic process | lymphocyte activation | positive regulation of molecular function | regulation of signaling receptor activity | receptor regulator activity | positive regulation of protein modification process | response to organic substance | regulation of JAK-STAT cascade | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | cell surface receptor signaling pathway | regulation of RNA biosynthetic process | negative regulation of programmed cell death | receptor ligand activity | immune response | cytokine activity | T cell proliferation | regulation of cell activation | positive regulation of NF-kappaB transcription factor activity | positive regulation of leukocyte migration | tumor necrosis factor-mediated signaling pathway | regulation of phosphate metabolic process | cell activation | lymphocyte proliferation | regulation of cell communication | signaling | regulation of transcription, DNA-templated | regulation of T cell proliferation | positive regulation of phosphorylation | positive regulation of metabolic process | immune system process | response to tumor necrosis factor | cellular response to organic substance | regulation of cell death | positive regulation of cell motility | negative regulation of cell death | positive regulation of signaling | signal transduction | regulation of signaling | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | cell | intrinsic component of membrane | plasma membrane | extracellular region | extracellular space | cell periphery | cell surface | membrane
