QuickView for TNSALP (gene)

Gene Symbol:

ALPL Homo sapiens

Full name:

alkaline phosphatase, liver/bone/kidney

Synonyms:

AP-TNAP, APTNAP, HOPS, TNAP, TNSALP, alkaline phosphatase, tissue-nonspecific isozyme, alkaline phosphatase liver/bone/kidney isozyme, liver/bone/kidney-type alkaline phosphatase, tissue-nonspecific ALP

Genomic Location:

Chr 1: 21708445-21777492

Description:

This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The pr...

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This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

FREAC7_01 ,  AAAGGGA_MIR204_MIR211 ,  GCCNNNWTAAR_UNKNOWN ,  AACATTC_MIR4093P

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-409-3p

Cytogenetic Map:

1p36.12

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