QuickView for TOCA1 (gene)
- Gene Symbol:
- FNBP1L
Homo sapiens - Full name:
- formin binding protein 1 like
- Synonyms:
- C1orf39, TOCA1, formin-binding protein 1-like, toca-1, transducer of Cdc42-dependent actin assembly 1, transducer of Cdc42-dependent actin assembly protein 1
- Genomic Location:
- Chr 1: 93737613-93792806
- Description:
-
The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Gallus gallus , Danio rerio , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
1p22.1
GO Molecular Function
GTPase binding | cadherin binding | enzyme binding | lipid binding | cell adhesion molecule binding | protein binding
GO Biological Process
actin filament-based process | positive regulation of cellular component organization | positive regulation of filopodium assembly | establishment of localization | membrane organization | vesicle cytoskeletal trafficking | intracellular transport | cellular process | establishment of organelle localization | localization | endomembrane system organization | establishment of localization in cell | actin filament-based movement | cytoskeleton-dependent intracellular transport | regulation of cellular process | catabolic process | organelle localization | cellular component organization | cellular localization | cellular component assembly | organelle assembly | regulation of cell projection assembly | plasma membrane organization | cell projection assembly | positive regulation of cell projection organization | vesicle-mediated transport | establishment of vesicle localization | autophagy | regulation of filopodium assembly | vesicle transport along actin filament | import into cell | cell projection organization | metabolic process | membrane invagination | endocytosis | clathrin-dependent endocytosis | positive regulation of cellular component biogenesis | cilium assembly | vesicle organization | vesicle budding from membrane | cilium organization | positive regulation of plasma membrane bounded cell projection assembly | receptor-mediated endocytosis | organelle organization | vesicle localization | regulation of cell projection organization | cellular metabolic process | plasma membrane tubulation | regulation of cellular component organization
GO Cellular Component
cytoplasmic vesicle | cell | cytoplasm | intracellular organelle | plasma membrane | vesicle | cytoplasmic region | cell cortex | membrane-bounded organelle | organelle | cell periphery | cytosol | intracellular vesicle | cytoskeleton | intracellular | membrane
