QuickView for TOP1 (gene)

Gene Symbol:

TOP1 Homo sapiens

Full name:

DNA topoisomerase I

Synonyms:

TOPI, DNA topoisomerase 1, topoisomerase (DNA) I, type I DNA topoisomerase

Genomic Location:

Chr 20: 39090876-39186541

Description:

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseu...

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This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ACAACTT_MIR382 ,  ACTGTAG_MIR139 ,  CCCACAT_MIR2993P ,  ATF6_01 ,  E2F1_Q4_01 ,  FOXO4_01 ,  YATGNWAAT_OCT_C ,  OCT_Q6 ,  YTATTTTNR_MEF2_02 ,  CACGTG_MYC_Q2 ,  SMAD3_Q6 ,  CATTGTYY_SOX9_B1 ,  CTACTGT_MIR199A ,  MAX_01 ,  CAGTGTT_MIR141_MIR200A ,  WHN_B ,  MYCMAX_02 ,  TGTATGA_MIR4853P ,  SOX9_B1 ,  ATCATGA_MIR433 ,  TAATGTG_MIR323 ,  CEBP_01 ,  ATF_01 ,  TTCYRGAA_UNKNOWN ,  MYCMAX_01 ,  ATF3_Q6 ,  AGTCTTA_MIR499 ,  GGGCGGR_SP1_Q6 ,  GTATGAT_MIR154_MIR487 ,  CEBPB_02 ,  IRF_Q6 ,  ACTGAAA_MIR30A3P_MIR30E3P ,  CTTTAAR_UNKNOWN ,  E2F_03 ,  E2F_Q4_01 ,  GFI1_01 ,  HLF_01 ,  AATGTGA_MIR23A_MIR23B ,  NMYC_01 ,  POU3F2_02 ,  TTGTTT_FOXO4_01 ,  ATF1_Q6 ,  GAGCCAG_MIR149 ,  IK1_01 ,  CTGAGCC_MIR24 ,  TGACAGNY_MEIS1_01 ,  ICSBP_Q6 ,  CTTTGT_LEF1_Q2 ,  RCGCANGCGY_NRF1_Q6 ,  NFKB_Q6_01 ,  ISRE_01 ,  AACTTT_UNKNOWN ,  GGCAGTG_MIR3243P ,  E2F_Q3_01 ,  NFKB_Q6 ,  ACCATTT_MIR522 ,  NFKB_C ,  SRF_C

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-139 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-208 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-324-3p ,  Predicted Gene Targets for miR-382 ,  Predicted Gene Targets for miR-433-3p ,  Predicted Gene Targets for miR-149 ,  Predicted Gene Targets for miR-299-3p ,  Predicted Gene Targets for miR-362 ,  Predicted Gene Targets for miR-375 ,  Predicted Gene Targets for miR-485-3p ,  Predicted Gene Targets for miR-499 ,  Predicted Gene Targets for miR-378

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Cytogenetic Map:

20q12

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