QuickView for TOPORS (gene)

Gene Symbol:

TOPORS Homo sapiens

Full name:

TOP1 binding arginine/serine rich protein

Synonyms:

LUN, P53BP3, RP31, TP53BPL, E3 ubiquitin-protein ligase Topors, RING-type E3 ubiquitin transferase Topors, SUMO1-protein E3 ligase Topors, topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase, topoisomerase I-binding RING finger protein, tumor suppressor p53-binding protein 3

Genomic Location:

Chr 9: 32530542-32542601

Description:

This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, ha...

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This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TCTGGAC_MIR198 ,  AAGCCAT_MIR135A_MIR135B ,  TCANNTGAY_SREBP1_01 ,  MYCMAX_03 ,  CACGTG_MYC_Q2 ,  MAX_01 ,  ARNT_02 ,  STAT_Q6 ,  TATCTGG_MIR488 ,  SREBP1_01 ,  YGCANTGCR_UNKNOWN ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  GGGCGGR_SP1_Q6 ,  NERF_Q2 ,  USF_01 ,  ATATGCA_MIR448 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  RCGCANGCGY_NRF1_Q6 ,  USF_02 ,  ACCATTT_MIR522

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-488

Cytogenetic Map:

9p21.1

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