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QuickView for TP1 (gene)


Gene Symbol:
TNP1 Homo sapiens Homo sapiens
Full name:
transition protein 1
Synonyms:
TP1, spermatid nuclear transition protein 1, STP-1, TP-1, transition protein 1 (during histone to protamine replacement)
Genomic Location:
Chr 2: 217432426-217433027
Description:
Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 2
2q35


Transcripts Names
NM_003284
Protein Names
Q4ZG82
P09430



GO Molecular Function

nucleic acid binding | DNA binding | organic cyclic compound binding | protein binding | heterocyclic compound binding

GO Biological Process

nucleus organization | cell motility | developmental process involved in reproduction | nucleosome organization | negative regulation of cellular process | negative regulation of RNA biosynthetic process | cell differentiation | male gamete generation | flagellated sperm motility | cellular process | regulation of gene expression, epigenetic | localization | chromatin organization | protein-DNA complex disassembly | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | regulation of proteolysis | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | gamete generation | regulation of cellular process | gene silencing | regulation of metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | cellular aromatic compound metabolic process | male pronucleus assembly | cellular component organization | positive regulation of protein processing | response to stimulus | positive regulation of protein metabolic process | sperm chromatin decondensation | response to stress | germ cell development | sperm motility | reproduction | positive regulation of proteolysis | cellular nitrogen compound metabolic process | negative regulation of metabolic process | spermatid differentiation | cellular component assembly | regulation of protein processing | DNA repair | regulation of nucleic acid-templated transcription | locomotion | nucleosome disassembly | organelle assembly | nitrogen compound metabolic process | reproductive process | multicellular organism development | single strand break repair | cellular response to DNA damage stimulus | ATP-dependent chromatin remodeling | regulation of gene expression | cellular response to stress | spermatid nucleus differentiation | negative regulation of gene expression, epigenetic | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | spermatogenesis, exchange of chromosomal proteins | regulation of cellular protein metabolic process | fertilization | fertilization, exchange of chromosomal proteins | regulation of cellular metabolic process | chromatin remodeling | regulation of protein metabolic process | regulation of RNA metabolic process | single fertilization | multicellular organism reproduction | DNA metabolic process | chromatin assembly or disassembly | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | spermatid development | DNA packaging | spermatid nucleus elongation | positive regulation of protein maturation | regulation of transcription, DNA-templated | cell development | histone exchange | protein-containing complex disassembly | developmental process | organelle organization | spermatogenesis | DNA conformation change | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | chromatin silencing | cellular metabolic process | sperm chromatin condensation | sexual reproduction | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | nuclear nucleosome | nucleosome | intracellular organelle | germ cell nucleus | protein-containing complex | protein-DNA complex | chromatin | nuclear chromosome | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromatin | intracellular | male germ cell nucleus