QuickView for TP53 (gene)
- Gene Symbol:
- TP53
Homo sapiens - Full name:
- tumor protein p53
- Synonyms:
- BCC7, LFS1, P53, TRP53, cellular tumor antigen p53, antigen NY-CO-13, mutant tumor protein 53, p53 tumor suppressor, phosphoprotein p53, transformation-related protein 53, tumor protein 53, tumor supressor p53
- Genomic Location:
- Chr 17: 7512445-7531642
- Description:
-
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are as...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Danio rerio , Gallus gallus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
17p13.1
GO Molecular Function
sequence-specific DNA binding | protein self-association | kinase binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | core promoter binding | protein phosphatase 2A binding | enhancer binding | cation binding | protein kinase binding | proximal promoter sequence-specific DNA binding | receptor tyrosine kinase binding | enzyme binding | nucleic acid binding | ribonucleotide binding | disordered domain specific binding | mRNA binding | nucleotide binding | signaling receptor binding | carbohydrate derivative binding | chromatin binding | chaperone binding | protein domain specific binding | ATP binding | protein N-terminus binding | ubiquitin-like protein ligase binding | TFIID-class transcription factor binding | anion binding | adenyl nucleotide binding | enhancer sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | p53 binding | DNA binding | sequence-specific double-stranded DNA binding | purine nucleotide binding | promoter-specific chromatin binding | identical protein binding | protein heterodimerization activity | ion binding | organic cyclic compound binding | protein tyrosine kinase binding | copper ion binding | transcription regulatory region sequence-specific DNA binding | purine ribonucleoside triphosphate binding | protein binding | histone acetyltransferase binding | zinc ion binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | protein phosphatase binding | transcription factor binding | ubiquitin protein ligase binding | RNA polymerase II transcription factor binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | RNA polymerase II distal enhancer sequence-specific DNA binding | transition metal ion binding | core promoter sequence-specific DNA binding | purine ribonucleotide binding | adenyl ribonucleotide binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding involved in preinitiation complex assembly | drug binding | transcription factor activity, core RNA polymerase binding | protease binding | phosphatase binding | mRNA 3'-UTR binding | histone deacetylase binding | metal ion binding | basal RNA polymerase II transcription machinery binding | heterocyclic compound binding | small molecule binding | RNA binding
GO Biological Process
protein modification by small protein removal | RNA metabolic process | transcription by RNA polymerase II | response to extracellular stimulus | protein homooligomerization | DNA-templated transcription, initiation | response to radiation | regulation of cell cycle process | cellular response to glucose starvation | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | regulation of intracellular protein transport | response to nutrient levels | response to endoplasmic reticulum stress | DNA strand renaturation | response to cytokine | positive regulation of cellular component organization | regulation of cellular localization | intracellular signal transduction | positive regulation of apoptotic process | proteolysis | regulation of localization | regulation of cell cycle G1/S phase transition | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | establishment of localization | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | regulation of protein localization to membrane | cell differentiation | positive regulation of intrinsic apoptotic signaling pathway | intrinsic apoptotic signaling pathway in response to DNA damage | cellular response to extracellular stimulus | response to drug | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | positive regulation of phosphate metabolic process | regulation of protein oligomerization | regulation of organelle organization | membrane organization | response to antibiotic | negative regulation of DNA metabolic process | positive regulation of cellular biosynthetic process | regulation of transcription initiation from RNA polymerase II promoter | cellular process | negative regulation of DNA biosynthetic process | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | localization | chromatin organization | mitotic DNA integrity checkpoint | negative regulation of G1/S transition of mitotic cell cycle | positive regulation of protein export from nucleus | positive regulation of reactive oxygen species metabolic process | negative regulation of nucleic acid-templated transcription | macromolecule localization | negative regulation of apoptotic process | positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | response to hypoxia | positive regulation of release of cytochrome c from mitochondria | cellular response to starvation | positive regulation of T cell apoptotic process | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | regulation of protein export from nucleus | negative regulation of cellular metabolic process | interspecies interaction between organisms | DNA geometric change | intrinsic apoptotic signaling pathway | regulation of lymphocyte apoptotic process | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | regulation of protein complex assembly | small GTPase mediated signal transduction | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | signal transduction involved in mitotic DNA damage checkpoint | cellular component organization | protein deubiquitination | response to UV | stress-induced premature senescence | response to stimulus | regulation of cellular protein localization | regulation of mitotic cell cycle phase transition | regulation of peptidyl-tyrosine phosphorylation | positive regulation of protein metabolic process | cellular response to light stimulus | cellular response to hypoxia | response to stress | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | response to peptide | regulation of cell cycle phase transition | circadian rhythm | response to starvation | response to actinomycin D | positive regulation of thymocyte apoptotic process | programmed cell death | protein-DNA complex assembly | rhythmic process | cellular nitrogen compound metabolic process | regulation of protein transport | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | protein modification process | mRNA metabolic process | regulation of peptide transport | cellular biosynthetic process | mitochondrion organization | macromolecule modification | regulation of intracellular transport | positive regulation of mitochondrion organization | DNA repair | regulation of nucleic acid-templated transcription | response to nitrogen compound | apoptotic process | cellular response to actinomycin D | regulation of cell cycle G2/M phase transition | response to light stimulus | cellular response to nutrient levels | response to oxygen levels | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | positive regulation of organelle organization | DNA damage response, signal transduction by p53 class mediator | negative regulation of growth | cellular response to antibiotic | mitotic DNA damage checkpoint | multicellular organism development | negative regulation of catalytic activity | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | cellular response to DNA damage stimulus | protein complex oligomerization | regulation of catalytic activity | cellular response to oxidative stress | ER-nucleus signaling pathway | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | DNA damage response, signal transduction resulting in transcription | positive regulation of cell cycle | signal transduction in response to DNA damage | regulation of gene expression | negative regulation of helicase activity | oligodendrocyte apoptotic process | regulation of mitochondrial membrane permeability | rhythmic behavior | cellular response to stress | cellular response to peptide | cell cycle | positive regulation of intracellular protein transport | regulation of signal transduction by p53 class mediator | regulation of cell cycle arrest | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of telomerase activity | cellular response to radiation | regulation of pri-miRNA transcription by RNA polymerase II | mitochondrial transport | cellular response to oxygen levels | glial cell apoptotic process | regulation of nitrogen compound metabolic process | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | positive regulation of protein complex assembly | regulation of transcription by RNA polymerase II | protein homotetramerization | cellular response to gamma radiation | response to oxidative stress | cellular response to cytokine stimulus | cell proliferation | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | positive regulation of transcription from RNA polymerase II promoter in response to stress | oxidative stress-induced premature senescence | positive regulation of pri-miRNA transcription by RNA polymerase II | regulation of RNA polymerase II transcriptional preinitiation complex assembly | cellular protein-containing complex assembly | protein tetramerization | positive regulation of leukocyte apoptotic process | regulation of apoptotic signaling pathway | DNA-templated transcriptional preinitiation complex assembly | signal transduction involved in cell cycle checkpoint | response to gamma radiation | RNA polymerase II transcriptional preinitiation complex assembly | cellular response to UV | autophagy | cellular response to drug | regulation of mitochondrion organization | mitotic G1 DNA damage checkpoint | mitochondrial membrane organization | cell communication | regulation of cellular metabolic process | positive regulation of protein localization to membrane | regulation of T cell apoptotic process | regulation of protein metabolic process | positive regulation of signal transduction | base-excision repair | mRNA transcription | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of RNA metabolic process | positive regulation of transport | viral process | negative regulation of cell growth | apoptotic signaling pathway | cell aging | ER overload response | regulation of mitotic cell cycle | regulation of nucleocytoplasmic transport | positive regulation of cell cycle arrest | positive regulation of execution phase of apoptosis | protein-containing complex assembly | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | regulation of fibroblast proliferation | DNA-binding transcription factor activity | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of growth | response to organic substance | G1 DNA damage checkpoint | cell cycle arrest | DNA metabolic process | replicative senescence | regulation of intracellular signal transduction | chromatin assembly or disassembly | anatomical structure development | mitotic cell cycle | cell surface receptor signaling pathway | entrainment of circadian clock | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | metabolic process | nucleotide-excision repair | regulation of DNA-templated transcription in response to stress | positive regulation of DNA-templated transcription, initiation | regulation of thymocyte apoptotic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | negative regulation of mitotic cell cycle | behavior | positive regulation of cell death | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | positive regulation of cellular component biogenesis | organic substance metabolic process | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | positive regulation of programmed cell death | signal transduction involved in mitotic cell cycle checkpoint | protein modification by small protein conjugation or removal | cellular response to ionizing radiation | regulation of phosphate metabolic process | regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | DNA packaging | intrinsic apoptotic signaling pathway by p53 class mediator | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | positive regulation of intracellular transport | positive regulation of lymphocyte apoptotic process | positive regulation of protein transport | chromatin assembly | negative regulation of cell cycle | multicellular organism aging | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | regulation of membrane permeability | negative regulation of molecular function | cellular senescence | signaling | regulation of transcription, DNA-templated | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | determination of adult lifespan | protein localization | negative regulation of fibroblast proliferation | positive regulation of phosphorylation | cellular protein metabolic process | regulation of transcription from RNA polymerase II promoter in response to stress | cellular macromolecule biosynthetic process | regulation of DNA-templated transcription, initiation | signal transduction involved in DNA damage checkpoint | response to biotic stimulus | regulation of circadian rhythm | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding involved in preinitiation complex assembly | transcription factor activity, core RNA polymerase binding | developmental process | organelle organization | regulation of DNA biosynthetic process | positive regulation of cell cycle process | regulation of cell growth | cellular protein modification process | mitotic G1/S transition checkpoint | negative regulation of transcription by RNA polymerase II | regulation of transport | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | positive regulation of protein oligomerization | negative regulation of cell proliferation | Ras protein signal transduction | circadian behavior | positive regulation of nucleic acid-templated transcription | entrainment of circadian clock by photoperiod | DNA conformation change | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | photoperiodism | heterocycle metabolic process | negative regulation of hydrolase activity | signal transduction involved in mitotic G1 DNA damage checkpoint | positive regulation of metabolic process | chromosome organization | regulation of execution phase of apoptosis | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | cellular response to organic substance | regulation of protein localization | regulation of cell death | DNA damage checkpoint | cell cycle checkpoint | signal transduction by p53 class mediator | negative regulation of cell death | aging | positive regulation of nucleocytoplasmic transport | negative regulation of telomerase activity | regulation of cellular component organization | response to ionizing radiation | positive regulation of transcription initiation from RNA polymerase II promoter | positive regulation of apoptotic signaling pathway | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
nuclear transcription factor complex | mitochondrial matrix | chromosome | intracellular membrane-bounded organelle | catalytic complex | RNA polymerase II transcription factor complex | cell | nuclear lumen | transcription factor complex | nucleolus | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear body | protein-containing complex | PML body | endomembrane system | nucleoplasm | chromatin | nuclear chromosome | transferase complex | mitochondrion | membrane-bounded organelle | nucleus | organelle | nuclear DNA-directed RNA polymerase complex | transcription factor TFIID complex | RNA polymerase complex | membrane-enclosed lumen | nuclear matrix | nuclear chromatin | cytosol | intracellular | RNA polymerase II, holoenzyme | nuclear periphery
