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QuickView for TP53I10 (gene)


Gene Symbol:
ENC1 Homo sapiens Homo sapiens
Full name:
ectodermal-neural cortex 1
Synonyms:
CCL28, ENC-1, KLHL35, KLHL37, NRPB, PIG10, TP53I10, ectoderm-neural cortex protein 1, ectodermal-neural cortex 1 (with BTB domain), ectodermal-neural cortex 1 (with BTB-like domain), kelch-like 35, kelch-like family member 37, kelch-like protein 37, nuclear matrix protein NRP/B, nuclear restricted protein, BTB domain-like (brain), p53-induced gene 10 protein, tumor protein p53 inducible protein 10
Genomic Location:
Chr 5: 73958990-73972273
Description:
This gene encodes a member of the kelch-related family of actin-binding proteins. The encoded protein plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation. Alternatively spliced transcript variants encoding multiple isoforms have been o...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 5
5q13.3





GO Molecular Function

actin binding | cytoskeletal protein binding | protein binding

GO Biological Process

positive regulation of cellular component organization | regulation of neurogenesis | proteolysis | regulation of cell development | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | nervous system development | neurogenesis | generation of neurons | cellular process | organic substance catabolic process | proteolysis involved in cellular protein catabolic process | regulation of neuron projection development | negative regulation of cellular metabolic process | regulation of cell differentiation | regulation of cellular process | regulation of metabolic process | catabolic process | posttranscriptional regulation of gene expression | cellular protein catabolic process | proteasomal protein catabolic process | negative regulation of metabolic process | protein modification process | macromolecule modification | system development | nitrogen compound metabolic process | positive regulation of neuron projection development | multicellular organism development | regulation of neuron differentiation | regulation of gene expression | protein catabolic process | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | positive regulation of cell projection organization | positive regulation of cell differentiation | regulation of cellular protein metabolic process | regulation of cellular metabolic process | regulation of protein metabolic process | proteasomal ubiquitin-independent protein catabolic process | protein metabolic process | protein ubiquitination | cellular macromolecule catabolic process | anatomical structure development | positive regulation of neurogenesis | metabolic process | positive regulation of cell development | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | negative regulation of cellular protein metabolic process | protein modification by small protein conjugation or removal | negative regulation of translation | negative regulation of protein metabolic process | organonitrogen compound catabolic process | cellular protein metabolic process | regulation of nervous system development | regulation of developmental process | developmental process | cellular protein modification process | positive regulation of neuron differentiation | regulation of cell projection organization | cellular metabolic process | regulation of translation | regulation of cellular component organization | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | catalytic complex | somatodendritic compartment | cell body | cell | nuclear lumen | neuronal cell body | Cul3-RING ubiquitin ligase complex | nucleolus | cytoplasm | intracellular organelle | ubiquitin ligase complex | protein-containing complex | nucleoplasm | chromatin | nuclear chromosome | transferase complex | cullin-RING ubiquitin ligase complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear matrix | nuclear chromatin | cytoskeleton | intracellular | nuclear periphery