QuickView for TPM4 (gene)

Gene Symbol:

TPM4 Homo sapiens

Full name:

tropomyosin 4

Synonyms:

HEL-S-108, tropomyosin alpha-4 chain, TM30p1, epididymis secretory protein Li 108

Genomic Location:

Chr 19: 16048325-16074408

Description:

This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments ...

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This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SP1_01 ,  ATF6_01 ,  CATTGTYY_SOX9_B1 ,  NGFIC_01 ,  ATF4_Q2 ,  CREB_Q4 ,  TGACCTY_ERR1_Q2 ,  GGGNRMNNYCAT_UNKNOWN ,  CREBP1_Q2 ,  ATF_01 ,  CACCAGC_MIR138 ,  EGR_Q6 ,  TGCTGAY_UNKNOWN ,  CAGCAGG_MIR370 ,  ATF1_Q6 ,  CREB_Q2 ,  EGR1_01 ,  CREB_Q2_01 ,  SP1_Q2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-370

miRNA binding sites
(Source: miRecords):

hsa-miR-1 Targeted Genes

Cytogenetic Map:

19p13.12-p13.11

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