QuickView for TRAAK (gene)

Gene Symbol:

KCNK4 Homo sapiens

Full name:

potassium two pore domain channel subfamily K member 4

Synonyms:

K2p4.1, TRAAK, TRAAK1, potassium channel subfamily K member 4, K2P4.1 potassium channel, TWIK-related arachidonic acid-stimulated potassium channel protein, potassium channel, subfamily K, member 4, potassium channel, two pore domain subfamily K, member 4, two pore K(+) channel KT4.1, two pore K+ channel KT4.1, two pore potassium channel KT4.1

Genomic Location:

Chr 11: 63815369-63824079

Description:

This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primari...

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This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RTAAACA_FREAC2_01 ,  ZIC3_01 ,  HNF3_Q6 ,  ACCAAAG_MIR9 ,  SPZ1_01 ,  CTTTGT_LEF1_Q2 ,  STAT5A_01 ,  ER_Q6_02

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-136 ,  Predicted Gene Targets for miR-9

Cytogenetic Map:

11q13.1

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