QuickView for TRAP1 (gene)
- Gene Symbol:
- TRAP1
Homo sapiens - Full name:
- TNF receptor associated protein 1
- Synonyms:
- HSP 75, HSP75, HSP90L, TRAP-1, heat shock protein 75 kDa, mitochondrial, TNFR-associated protein 1, testicular tissue protein Li 209, tumor necrosis factor type 1 receptor-associated protein
- Genomic Location:
- Chr 16: 3648039-3707599
- Description:
-
This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
16p13.3
GO Molecular Function
kinase binding | protein kinase binding | enzyme binding | nucleic acid binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | carbohydrate derivative binding | cytokine receptor binding | unfolded protein binding | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | tumor necrosis factor receptor binding | purine ribonucleoside triphosphate binding | protein binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | tumor necrosis factor receptor superfamily binding | heterocyclic compound binding | small molecule binding | RNA binding
GO Biological Process
regulation of hydrogen peroxide-induced cell death | regulation of cellular response to oxidative stress | regulation of response to oxidative stress | regulation of programmed cell death | negative regulation of cellular response to oxidative stress | negative regulation of cellular process | cellular process | chaperone-mediated protein folding | negative regulation of signaling | negative regulation of apoptotic process | negative regulation of cellular metabolic process | negative regulation of apoptotic signaling pathway | negative regulation of hydrogen peroxide-mediated programmed cell death | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | negative regulation of oxidative stress-induced cell death | negative regulation of response to drug | response to stimulus | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | response to stress | regulation of response to drug | posttranscriptional regulation of gene expression | negative regulation of metabolic process | negative regulation of reactive oxygen species biosynthetic process | regulation of cellular response to stress | regulation of signal transduction | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | regulation of intrinsic apoptotic signaling pathway | regulation of gene expression | negative regulation of hydrogen peroxide-induced cell death | regulation of nitrogen compound metabolic process | regulation of cellular protein metabolic process | regulation of apoptotic signaling pathway | regulation of cellular response to drug | regulation of cellular metabolic process | regulation of protein metabolic process | negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide | regulation of cellular respiration | regulation of response to reactive oxygen species | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | negative regulation of response to oxidative stress | negative regulation of programmed cell death | negative regulation of cellular respiration | negative regulation of intrinsic apoptotic signaling pathway | protein folding | negative regulation of biosynthetic process | translational attenuation | regulation of reactive oxygen species biosynthetic process | regulation of cell communication | negative regulation of signal transduction | regulation of reactive oxygen species metabolic process | regulation of generation of precursor metabolites and energy | regulation of cell death | regulation of translation | negative regulation of cell death | negative regulation of reactive oxygen species metabolic process | regulation of signaling
GO Cellular Component
mitochondrial matrix | mitochondrial intermembrane space | organelle inner membrane | intracellular membrane-bounded organelle | mitochondrial inner membrane | organelle membrane | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | mitochondrion | membrane-bounded organelle | nucleus | organelle | mitochondrial envelope | membrane-enclosed lumen | mitochondrial membrane | intracellular | membrane
