QuickView for TREM2 (gene)

Gene Symbol:

TREM2 Homo sapiens

Full name:

triggering receptor expressed on myeloid cells 2

Synonyms:

TREM-2, Trem2a, Trem2b, Trem2c, triggering receptor expressed on myeloid cells 2, triggering receptor expressed on monocytes 2, triggering receptor expressed on myeloid cells 2a

Genomic Location:

Chr 6: 41234230-41238892

Description:

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembr...

View Full Description

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Cytogenetic Map:

6p21.1

search → result