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QuickView for TRIAD3 (gene)

Gene Symbol:
RNF216 Homo sapiens Homo sapiens
Full name:
ring finger protein 216
CAHH, TRIAD3, U7I1, UBCE7IP1, ZIN, E3 ubiquitin-protein ligase RNF216, RING-type E3 ubiquitin transferase RNF216, triad domain-containing protein 3, ubiquitin-conjugating enzyme 7-interacting protein 1, zinc finger protein inhibiting NF-kappa-B
Genomic Location:
Chr 7: 5626204-5787818
This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may als...
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 7

GO Molecular Function

cation binding | catalytic activity | ubiquitin-like protein transferase activity | ubiquitin protein ligase activity | ion binding | protein binding | ubiquitin-protein transferase activity | transferase activity | ubiquitin-like protein ligase activity | metal ion binding

GO Biological Process

negative regulation of type I interferon production | proteolysis | regulation of immune system process | cellular process | organic substance catabolic process | proteolysis involved in cellular protein catabolic process | regulation of defense response to virus | interspecies interaction between organisms | regulation of interferon-beta production | catabolic process | regulation of type I interferon production | programmed cell death | cellular protein catabolic process | proteasomal protein catabolic process | protein modification process | macromolecule modification | apoptotic process | nitrogen compound metabolic process | protein catabolic process | negative regulation of cytokine production | protein modification by small protein conjugation | ubiquitin protein ligase activity | viral process | proteasome-mediated ubiquitin-dependent protein catabolic process | protein polyubiquitination | protein metabolic process | protein ubiquitination | cellular macromolecule catabolic process | metabolic process | ubiquitin-protein transferase activity | organic substance metabolic process | cell death | protein modification by small protein conjugation or removal | ubiquitin-dependent protein catabolic process | organonitrogen compound catabolic process | cellular protein metabolic process | regulation of cytokine production | cellular protein modification process | regulation of defense response to virus by host | protein K48-linked ubiquitination | cellular metabolic process | modification-dependent protein catabolic process | macromolecule metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular