QuickView for TRIAD3 (gene)

Gene Symbol:

RNF216 Homo sapiens

Full name:

ring finger protein 216

Synonyms:

CAHH, TRIAD3, U7I1, UBCE7IP1, ZIN, E3 ubiquitin-protein ligase RNF216, RING-type E3 ubiquitin transferase RNF216, triad domain-containing protein 3, ubiquitin-conjugating enzyme 7-interacting protein 1, zinc finger protein inhibiting NF-kappa-B

Genomic Location:

Chr 7: 5626204-5787818

Description:

This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may als...

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This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GGGAGGRR_MAZ_Q6 ,  RP58_01 ,  WCTCNATGGY_UNKNOWN ,  TTGTTT_FOXO4_01 ,  RCGCANGCGY_NRF1_Q6 ,  CAGCTG_AP4_Q5

Cytogenetic Map:

7p22.1

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