QuickView for TRIM2;jsessionid=FFA447381F863C13E2731103189AEDA2 (gene)
- Gene Symbol:
- TRIM2
Homo sapiens - Full name:
- tripartite motif containing 2
- Synonyms:
- CMT2R, RNF86, tripartite motif-containing protein 2, E3 ubiquitin-protein ligase TRIM2, RING finger protein 86, RING-type E3 ubiquitin transferase TRIM2, tripartite motif protein TRIM2
- Genomic Location:
- Chr 4: 154345068-154479918
- Description:
-
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated de...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-1 , Predicted Gene Targets for miR-10 , Predicted Gene Targets for miR-101 , Predicted Gene Targets for miR-130 , Predicted Gene Targets for miR-132 , Predicted Gene Targets for miR-133 , Predicted Gene Targets for miR-144 , Predicted Gene Targets for miR-145 , Predicted Gene Targets for miR-148 , Predicted Gene Targets for miR-15
- miRNA binding sites
(Source: miRecords):
- Cytogenetic Map:
-
4q31.3
GO Molecular Function
cation binding | catalytic activity | ubiquitin-like protein transferase activity | ubiquitin protein ligase activity | ion binding | protein binding | zinc ion binding | ubiquitin-protein transferase activity | transferase activity | transition metal ion binding | ubiquitin-like protein ligase activity | metal ion binding
GO Biological Process
proteolysis | regulation of programmed cell death | regulation of neuron death | cellular process | organic substance catabolic process | proteolysis involved in cellular protein catabolic process | regulation of cellular process | regulation of apoptotic process | catabolic process | cellular protein catabolic process | proteasomal protein catabolic process | protein modification process | macromolecule modification | nitrogen compound metabolic process | protein catabolic process | protein modification by small protein conjugation | ubiquitin protein ligase activity | regulation of neuron apoptotic process | proteasome-mediated ubiquitin-dependent protein catabolic process | protein polyubiquitination | protein metabolic process | protein ubiquitination | cellular macromolecule catabolic process | metabolic process | ubiquitin-protein transferase activity | organic substance metabolic process | protein modification by small protein conjugation or removal | ubiquitin-dependent protein catabolic process | organonitrogen compound catabolic process | cellular protein metabolic process | cellular protein modification process | cellular metabolic process | regulation of cell death | modification-dependent protein catabolic process | macromolecule metabolic process
