QuickView for TRIM23 (gene)

Gene Symbol:

TRIM23 Homo sapiens

Full name:

tripartite motif containing 23

Synonyms:

ARD1, ARFD1, RNF46, E3 ubiquitin-protein ligase TRIM23, ADP-ribosylation factor domain protein 1, 64kDa, ADP-ribosylation factor domain-containing protein 1, ARF domain protein 1, GTP-binding protein ARD-1, RING finger protein 46, RING-type E3 ubiquitin transferase TRIM23, tripartite motif protein TRIM23, tripartite motif-containing protein 23

Genomic Location:

Chr 5: 64921263-64955943

Description:

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contai...

View Full Description

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E12_Q6 ,  AAGCCAT_MIR135A_MIR135B ,  GCANCTGNY_MYOD_Q6 ,  CTTTGCA_MIR527 ,  IRF1_Q6 ,  ACTGTGA_MIR27A_MIR27B ,  CTTTGTA_MIR524 ,  TCCCRNNRTGC_UNKNOWN ,  CAGGTG_E12_Q6 ,  E47_02 ,  AHR_Q5 ,  ACTAYRNNNCCCR_UNKNOWN ,  AHRARNT_01 ,  GFI1_01 ,  WCAANNNYCAG_UNKNOWN ,  CTGTTAC_MIR194 ,  LMO2COM_01

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-137

Cytogenetic Map:

5q12.3

search → result