QuickView for TRPM2B (gene)
- Gene Symbol:
- Clu
Rattus norvegicus - Full name:
- clusterin
- Synonyms:
- APOJ, CLI, DAG, RATTRPM2B, SGP-2, SGP2, SP-40, SP40, TRPM-2, TRPM2B, Trpm2, Trpmb, clusterin, dimeric acid glycoprotein, sulfated glycoprotein 2, testosterone repressed prostate message 2, testosterone-repressed prostate message, testostrone-repressed prostate message 2
- Genomic Location:
- Chr 15: 45365779-45405314
- Description:
-
The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders.
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Bos taurus , Danio rerio , Gallus gallus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
GATA1_01 , CEBP_Q2 , STAT_01 , LMO2COM_02 , STAT5B_01 , STAT_Q6 , GATA_Q6 , SYATTGTG_UNKNOWN , TCCATTKW_UNKNOWN , TTANWNANTGGM_UNKNOWN
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
peptide binding | low-density lipoprotein particle receptor binding | amyloid-beta binding | enzyme binding | protein-containing complex binding | lipoprotein particle receptor binding | signaling receptor binding | hydrolase activity | ATPase activity | pyrophosphatase activity | catalytic activity | chaperone binding | protein N-terminus binding | ubiquitin-like protein ligase binding | cytoskeletal protein binding | nucleoside-triphosphatase activity | tau protein binding | amide binding | protein binding | misfolded protein binding | ubiquitin protein ligase binding | hydrolase activity, acting on acid anhydrides | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO Biological Process
negative regulation of amyloid-beta formation | regulation of supramolecular fiber organization | response to radiation | cell morphogenesis | glial cell proliferation | positive regulation of amyloid precursor protein catabolic process | response to virus | positive regulation of cellular component organization | neuron projection morphogenesis | intracellular signal transduction | positive regulation of apoptotic process | protein stabilization | regulation of localization | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | establishment of localization | negative regulation of protein homooligomerization | regulation of nitric oxide biosynthetic process | negative regulation of cellular process | positive regulation of developmental process | response to potassium ion | response to metal ion | cell differentiation | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | response to misfolded protein | male gamete generation | positive regulation of intrinsic apoptotic signaling pathway | nervous system development | positive regulation of protein catabolic process | negative regulation of cellular response to thapsigargin | cell part morphogenesis | positive regulation of tau-protein kinase activity | neurogenesis | positive regulation of phosphate metabolic process | regulation of protein oligomerization | generation of neurons | membrane organization | microglial cell proliferation | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | localization | axon ensheathment | cell projection morphogenesis | chaperone-mediated protein folding | protein transport | negative regulation of signaling | neuron development | positive regulation of reactive oxygen species metabolic process | positive regulation of neurofibrillary tangle assembly | multicellular organismal reproductive process | positive regulation of protein kinase activity | macromolecule localization | negative regulation of response to endoplasmic reticulum stress | negative regulation of apoptotic process | endomembrane system organization | regulation of proteolysis | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | myelin maintenance | response to inorganic substance | central nervous system myelination | negative regulation of cellular metabolic process | regulation of cell differentiation | gamete generation | intrinsic apoptotic signaling pathway | negative regulation of apoptotic signaling pathway | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | gliogenesis | regulation of protein complex assembly | positive regulation of cellular protein metabolic process | response to topologically incorrect protein | endocrine pancreas development | cellular component organization | positive regulation of tumor necrosis factor production | positive regulation of cellular protein catabolic process | response to stimulus | oligodendrocyte development | positive regulation of nitric oxide metabolic process | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | regulation of neuronal signal transduction | negative regulation of cellular response to tunicamycin | response to stress | regulation of response to endoplasmic reticulum stress | regulation of cell proliferation | ovulation cycle | ensheathment of neurons | axon ensheathment in central nervous system | programmed cell death | positive regulation of proteolysis involved in cellular protein catabolic process | reproduction | rhythmic process | positive regulation of proteolysis | negative regulation of protein oligomerization | negative regulation of metabolic process | cellular component assembly | negative regulation of amyloid precursor protein catabolic process | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | regulation of neurotransmitter levels | apoptotic process | positive regulation of reactive oxygen species biosynthetic process | response to light stimulus | response to external biotic stimulus | system development | reproductive process | regulation of signal transduction | regulation of protein stability | myelination | multicellular organism development | negative regulation of amyloid fibril formation | regulation of tau-protein kinase activity | regulation of catalytic activity | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | plasma membrane organization | regulation of receptor-mediated endocytosis | positive regulation of receptor-mediated endocytosis | regulation of gene expression | pancreas development | organic substance transport | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | peptide transport | positive regulation of intracellular signal transduction | positive regulation of protein complex assembly | positive regulation of cell differentiation | central nervous system myelin maintenance | cell proliferation | leukocyte proliferation | regulation of cellular protein metabolic process | positive regulation of proteasomal protein catabolic process | glial cell differentiation | cellular protein-containing complex assembly | positive regulation of neuron death | regulation of apoptotic signaling pathway | microglial cell activation | endocrine system development | regulation of tumor necrosis factor production | regulation of amyloid precursor protein catabolic process | protein import | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of RNA metabolic process | positive regulation of transport | apoptotic signaling pathway | positive regulation of molecular function | regulation of proteasomal ubiquitin-dependent protein catabolic process | neuron differentiation | multicellular organism reproduction | protein-containing complex assembly | regulation of protein homooligomerization | positive regulation of protein modification process | response to organic substance | regulation of kinase activity | response to wounding | chaperone-mediated protein complex assembly | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | cell projection organization | positive regulation of ubiquitin-dependent protein catabolic process | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of programmed cell death | regulation of amyloid fibril formation | regulation of proteasomal protein catabolic process | regulation of amyloid-beta clearance | oligodendrocyte differentiation | amide transport | regulation of vesicle-mediated transport | positive regulation of cell death | regulation of response to DNA damage stimulus | macrophage activation | neuron projection development | negative regulation of protein complex assembly | positive regulation of cellular component biogenesis | negative regulation of intrinsic apoptotic signaling pathway | protein folding | regulation of intrinsic apoptotic signaling pathway in response to DNA damage | cell death | animal organ development | positive regulation of NF-kappaB transcription factor activity | positive regulation of programmed cell death | positive regulation of kinase activity | regulation of phosphate metabolic process | establishment of protein localization | positive regulation of cytokine production | cell activation | regulation of reactive oxygen species biosynthetic process | negative regulation of protein metabolic process | estrous cycle | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | glial cell development | regulation of amyloid-beta formation | cell development | positive regulation of protein homooligomerization | regulation of endocytosis | protein localization | positive regulation of phosphorylation | regulation of cytokine production | anatomical structure morphogenesis | response to biotic stimulus | regulation of developmental process | developmental process | spermatogenesis | regulation of inclusion body assembly | positive regulation of inclusion body assembly | regulation of transport | regulation of reactive oxygen species metabolic process | positive regulation of protein oligomerization | negative regulation of supramolecular fiber organization | positive regulation of nitric oxide biosynthetic process | central nervous system development | positive regulation of metabolic process | immune system process | positive regulation of amyloid-beta formation | cellular response to organic substance | regulation of cell death | negative regulation of cell death | aging | regulation of ubiquitin-dependent protein catabolic process | sexual reproduction | positive regulation of endocytosis | regulation of cellular component organization | positive regulation of apoptotic signaling pathway | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | cellular response to growth factor stimulus | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
secretory granule | chromaffin granule | dendrite | intracellular membrane-bounded organelle | neuron projection | extracellular matrix | somatodendritic compartment | organelle membrane | cytoplasmic vesicle | cell | distal axon | spherical high-density lipoprotein particle | cytoplasm | collagen-containing extracellular matrix | intracellular organelle | lipoprotein particle | endoplasmic reticulum | dendritic tree | inclusion body | Golgi apparatus | protein-containing complex | cell projection | secretory vesicle | endomembrane system | protein-lipid complex | vesicle | perinuclear region of cytoplasm | mitochondrion | site of polarized growth | extracellular region | membrane-bounded organelle | aggresome | nucleus | organelle | mitochondrial envelope | high-density lipoprotein particle | extracellular space | apical dendrite | cell periphery | axon | plasma lipoprotein particle | growth cone | mitochondrial membrane | cytosol | intracellular vesicle | cell surface | cytoskeleton | intracellular | neurofibrillary tangle | membrane
